{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["161(3)"],"submitter":["Poppe JP"],"funding":["Paracelsus Medical University"],"pubmed_abstract":["<h4>Purpose</h4>To assess the impact of individual surgeon experience on overall survival (OS), extent of resection (EOR) and surgery-related morbidity in elderly patients with glioblastoma (GBM), we performed a retrospective case-by-case analysis.<h4>Methods</h4>GBM patients aged ≥ 65 years who underwent tumor resection at two academic centers were analyzed. The experience of each neurosurgeon was quantified in three ways: (1) total number of previously performed glioma surgeries (lifetime experience); (2) number of surgeries performed in the previous five years (medium-term experience) and (3) in the last two years (short-term experience). Surgeon experience data was correlated with survival (OS) and surrogate parameters for surgical quality (EOR, morbidity).<h4>Results</h4>198 GBM patients (median age 73.0 years, median preoperative KPS 80, IDH-wildtype status 96.5%) were included. Median OS was 10.0 months (95% CI 8.0-12.0); median EOR was 89.4%. Surgery-related morbidity affected 19.7% patients. No correlations of lifetime surgeon experience with OS (P = .693), EOR (P = .693), and surgery-related morbidity (P = .435) were identified. Adjuvant therapy was associated with improved OS (P < .001); patients with surgery-related morbidity were less likely to receive adjuvant treatment (P = .002). In multivariable testing, adjuvant therapy (P < .001; HR = 0.064, 95%CI 0.028-0.144) remained the only significant predictor for improved OS.<h4>Conclusion</h4>Less experienced neurosurgeons achieve similar surgical results and outcome in elderly GBM patients within the setting of academic teaching hospitals. Adjuvant treatment and avoidance of surgery-related morbidity are crucial for generating a treatment benefit for this cohort."],"journal":["Journal of neuro-oncology"],"pagination":["563-572"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9992256"],"repository":["biostudies-literature"],"pubmed_title":["Surgeon experience in glioblastoma surgery of the elderly-a multicenter, retrospective cohort study."],"pmcid":["PMC9992256"],"pubmed_authors":["Steinbacher J","Griessenauer CJ","Ladisich B","Jahromi BR","Machegger L","Demetz M","Korja M","Niemela M","Poppe JP","Kraus TFJ","Spiegl-Kreinecker S","Romagna A","Schwartz C","Gruber A","Stefanits H","Eisschiel S","Weis S","Rautalin I"],"additional_accession":[]},"is_claimable":false,"name":"Surgeon experience in glioblastoma surgery of the elderly-a multicenter, retrospective cohort study.","description":"<h4>Purpose</h4>To assess the impact of individual surgeon experience on overall survival (OS), extent of resection (EOR) and surgery-related morbidity in elderly patients with glioblastoma (GBM), we performed a retrospective case-by-case analysis.<h4>Methods</h4>GBM patients aged ≥ 65 years who underwent tumor resection at two academic centers were analyzed. The experience of each neurosurgeon was quantified in three ways: (1) total number of previously performed glioma surgeries (lifetime experience); (2) number of surgeries performed in the previous five years (medium-term experience) and (3) in the last two years (short-term experience). Surgeon experience data was correlated with survival (OS) and surrogate parameters for surgical quality (EOR, morbidity).<h4>Results</h4>198 GBM patients (median age 73.0 years, median preoperative KPS 80, IDH-wildtype status 96.5%) were included. Median OS was 10.0 months (95% CI 8.0-12.0); median EOR was 89.4%. Surgery-related morbidity affected 19.7% patients. No correlations of lifetime surgeon experience with OS (P = .693), EOR (P = .693), and surgery-related morbidity (P = .435) were identified. Adjuvant therapy was associated with improved OS (P < .001); patients with surgery-related morbidity were less likely to receive adjuvant treatment (P = .002). In multivariable testing, adjuvant therapy (P < .001; HR = 0.064, 95%CI 0.028-0.144) remained the only significant predictor for improved OS.<h4>Conclusion</h4>Less experienced neurosurgeons achieve similar surgical results and outcome in elderly GBM patients within the setting of academic teaching hospitals. Adjuvant treatment and avoidance of surgery-related morbidity are crucial for generating a treatment benefit for this cohort.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-22T13:10:27.619Z","creation":"2025-04-06T00:32:28.083Z"},"accession":"S-EPMC9992256","cross_references":{"pubmed":["36719614"],"doi":["10.1007/s11060-023-04252-3"]}}