{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Field DH"],"funding":["University of Leeds","Leverhulme Trust","Royal Society","Wellcome Trust","Engineering and Physical Sciences Research Council"],"pagination":["216-222"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9994102"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(3)"],"pubmed_abstract":["Fluorescent ligands for G-protein coupled receptors (GPCRs) are valuable tools for studying the expression, pharmacology and modulation of these therapeutically important proteins in living cells. Here we report a fluorescent photoaffinity probe for Formyl peptide receptor 1 (FPR1), a critical component of the innate immune response to bacterial infection and a promising target in inflammatory diseases. We demonstrate that the probe binds and covalently crosslinks to FPR1 with good specificity at nanomolar concentrations in living cells and is a useful tool for visualisation and characterisation of this receptor."],"journal":["RSC chemical biology"],"pubmed_title":["A fluorescent photoaffinity probe for formyl peptide receptor 1 labelling in living cells."],"pmcid":["PMC9994102"],"funding_grant_id":["RG160914","1930246","WT104918MA","RPG-2018-030"],"pubmed_authors":["Wright MH","Field DH","White JS","Warriner SL"],"additional_accession":[]},"is_claimable":false,"name":"A fluorescent photoaffinity probe for formyl peptide receptor 1 labelling in living cells.","description":"Fluorescent ligands for G-protein coupled receptors (GPCRs) are valuable tools for studying the expression, pharmacology and modulation of these therapeutically important proteins in living cells. Here we report a fluorescent photoaffinity probe for Formyl peptide receptor 1 (FPR1), a critical component of the innate immune response to bacterial infection and a promising target in inflammatory diseases. We demonstrate that the probe binds and covalently crosslinks to FPR1 with good specificity at nanomolar concentrations in living cells and is a useful tool for visualisation and characterisation of this receptor.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-05-28T22:45:22.667Z","creation":"2025-04-04T20:21:47.736Z"},"accession":"S-EPMC9994102","cross_references":{"pubmed":["36908701"],"doi":["10.1039/d2cb00199c"]}}