biostudies-literatureLuigi LMedical Research Council100054https://www.ebi.ac.uk/biostudies/studies/S-EPMC9997148biostudies-literatureUnknown2Gray matter networks are altered with amyloid accumulation in the earliest stage of AD, and are associated with decline throughout the AD spectrum. It remains unclear to what extent gray matter network abnormalities are associated with hyperphosphorylated-tau (p-tau). We studied the relationship of cerebrospinal fluid (CSF) p-tau181 with gray matter networks in non-demented participants from the European Prevention of Alzheimer's Dementia (EPAD) cohort, and studied dependencies on amyloid and cognitive status. Gray matter networks were extracted from baseline structural 3D T1w MRI. P-tau181 and abeta were measured with the Roche cobas Elecsys System. We studied the associations of CSF biomarkers levels with several network's graph properties. We further studied whether the relationships ofAging brainGray matter network properties show distinct associations with CSF p-tau 181 levels and amyloid status in individuals without dementia.PMC9997148UKDRI-4002Philip SSven HPierre PSilvia IGael CJoanna WCraig RPablo MLGispert JDLuigi LViktor WWink AMTijms BMKaj BGiovanni FBO'Brien JTFrederik BMutsaerts HJVisser PJAdam WfalseGray matter network properties show distinct associations with CSF p-tau 181 levels and amyloid status in individuals without dementia.Gray matter networks are altered with amyloid accumulation in the earliest stage of AD, and are associated with decline throughout the AD spectrum. It remains unclear to what extent gray matter network abnormalities are associated with hyperphosphorylated-tau (p-tau). We studied the relationship of cerebrospinal fluid (CSF) p-tau181 with gray matter networks in non-demented participants from the European Prevention of Alzheimer's Dementia (EPAD) cohort, and studied dependencies on amyloid and cognitive status. Gray matter networks were extracted from baseline structural 3D T1w MRI. P-tau181 and abeta were measured with the Roche cobas Elecsys System. We studied the associations of CSF biomarkers levels with several network's graph properties. We further studied whether the relationships of2022-01-01T00:00:00Z20222026-03-17T16:17:49.573Z2025-04-04T11:27:11.454ZS-EPMC99971483690889810.1016/j.nbas.2022.100054