{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma W"],"funding":["Natural Science Foundation of Shandong Province","Cultivate Fund from The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital","Clinical &amp; Medical Science and Technology Innovation Program of Jinan","Cultivate Fund from The First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital","Clinical & Medical Science and Technology Innovation Program of Jinan"],"pagination":["471-480"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9998317"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(4)"],"pubmed_abstract":["The widespread of different NDM variants in clinical Enterobacterales isolates poses a serious public health concern, which requires continuous monitoring. In this study, three E. coli strains carrying two novel bla<sub>NDM</sub> variants of bla<sub>NDM-36, -37</sub> were identified from a patient with refractory urinary tract infection (UTI) in China. We conducted antimicrobial susceptibility testing (AST), enzyme kinetics analysis, conjugation experiment, whole-genome sequencing (WGS), and bioinformatics analysis to characterize the bla<sub>NDM-36, -37</sub> enzymes and their carrying strains. The bla<sub>NDM-36, -37</sub> harboring E. coli isolates belonged to ST227, O9:H10 serotype and exhibited intermediate or resistance to all β-lactams tested except aztreonam and aztreonam/avibactam"],"journal":["European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology"],"pubmed_title":["Genetic and enzymatic characterization of two novel bla<sub>NDM-36, -37</sub> variants in Escherichia coli strains."],"pmcid":["PMC9998317"],"funding_grant_id":["QYPY2022NSFC0802","ZR2021MH078","202134040"],"pubmed_authors":["Cheng F","Dong X","Chen L","Hao M","Cui X","Zhu B","Shi X","Ma W","Li X","Niu S","Wang Q","Wang W","Ma J","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Genetic and enzymatic characterization of two novel bla<sub>NDM-36, -37</sub> variants in Escherichia coli strains.","description":"The widespread of different NDM variants in clinical Enterobacterales isolates poses a serious public health concern, which requires continuous monitoring. In this study, three E. coli strains carrying two novel bla<sub>NDM</sub> variants of bla<sub>NDM-36, -37</sub> were identified from a patient with refractory urinary tract infection (UTI) in China. We conducted antimicrobial susceptibility testing (AST), enzyme kinetics analysis, conjugation experiment, whole-genome sequencing (WGS), and bioinformatics analysis to characterize the bla<sub>NDM-36, -37</sub> enzymes and their carrying strains. The bla<sub>NDM-36, -37</sub> harboring E. coli isolates belonged to ST227, O9:H10 serotype and exhibited intermediate or resistance to all β-lactams tested except aztreonam and aztreonam/avibactam","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-05-29T20:46:54.17Z","creation":"2024-11-07T08:46:02.831Z"},"accession":"S-EPMC9998317","cross_references":{"pubmed":["36810726"],"doi":["10.1007/s10096-023-04576-y"]}}