{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["36(2)"],"submitter":["Seikrit C"],"funding":["Dr. Werner Jackstädt-Stiftung","RWTH Aachen University"],"pubmed_abstract":["<h4>Background</h4>A dysregulated 'gut-kidney axis' may contribute to immunoglobulin A nephropathy (IgAN). We studied whether IgAN patients have disturbed intestinal permeability.<h4>Methods</h4>In a prospective, cross sectional, pilot study we assessed intestinal permeability in 35 IgAN patients, 18 patients with non-IgAN glomerulonephritides (GNs) and 19 healthy controls. After an overnight fast, trial participants ingested a multi-sugar solution and samples were obtained from 0 to 2, 2 to 5- and 5 to 24-h urine portions. Urinary sugar concentrations were quantified using isocratic ion-exchange high performance liquid chromatography. Indices of small intestinal permeability (0-2-h lactulose/L-rhamnose (L/R) ratio), distal small intestinal and proximal colonic permeability (2-5-h sucralos"],"journal":["Journal of nephrology"],"pagination":["463-474"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9998562"],"repository":["biostudies-literature"],"pubmed_title":["Intestinal permeability in patients with IgA nephropathy and other glomerular diseases: an observational study."],"pmcid":["PMC9998562"],"pubmed_authors":["Stamellou E","Pabst O","Lenaerts K","Schimpf JI","Rauen T","Wied S","Floege J","Izcue A","Seikrit C"],"additional_accession":[]},"is_claimable":false,"name":"Intestinal permeability in patients with IgA nephropathy and other glomerular diseases: an observational study.","description":"<h4>Background</h4>A dysregulated 'gut-kidney axis' may contribute to immunoglobulin A nephropathy (IgAN). We studied whether IgAN patients have disturbed intestinal permeability.<h4>Methods</h4>In a prospective, cross sectional, pilot study we assessed intestinal permeability in 35 IgAN patients, 18 patients with non-IgAN glomerulonephritides (GNs) and 19 healthy controls. After an overnight fast, trial participants ingested a multi-sugar solution and samples were obtained from 0 to 2, 2 to 5- and 5 to 24-h urine portions. Urinary sugar concentrations were quantified using isocratic ion-exchange high performance liquid chromatography. Indices of small intestinal permeability (0-2-h lactulose/L-rhamnose (L/R) ratio), distal small intestinal and proximal colonic permeability (2-5-h sucralos","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-04T14:17:02.85Z","creation":"2025-02-19T02:23:03.278Z"},"accession":"S-EPMC9998562","cross_references":{"pubmed":["36107369"],"doi":["10.1007/s40620-022-01454-2"]}}