biostudies-literatureUnknown36(2)Seikrit CDr. Werner Jackstädt-StiftungRWTH Aachen University<h4>Background</h4>A dysregulated 'gut-kidney axis' may contribute to immunoglobulin A nephropathy (IgAN). We studied whether IgAN patients have disturbed intestinal permeability.<h4>Methods</h4>In a prospective, cross sectional, pilot study we assessed intestinal permeability in 35 IgAN patients, 18 patients with non-IgAN glomerulonephritides (GNs) and 19 healthy controls. After an overnight fast, trial participants ingested a multi-sugar solution and samples were obtained from 0 to 2, 2 to 5- and 5 to 24-h urine portions. Urinary sugar concentrations were quantified using isocratic ion-exchange high performance liquid chromatography. Indices of small intestinal permeability (0-2-h lactulose/L-rhamnose (L/R) ratio), distal small intestinal and proximal colonic permeability (2-5-h sucralosJournal of nephrology463-474https://www.ebi.ac.uk/biostudies/studies/S-EPMC9998562biostudies-literatureIntestinal permeability in patients with IgA nephropathy and other glomerular diseases: an observational study.PMC9998562Stamellou EPabst OLenaerts KSchimpf JIRauen TWied SFloege JIzcue ASeikrit CfalseIntestinal permeability in patients with IgA nephropathy and other glomerular diseases: an observational study.<h4>Background</h4>A dysregulated 'gut-kidney axis' may contribute to immunoglobulin A nephropathy (IgAN). We studied whether IgAN patients have disturbed intestinal permeability.<h4>Methods</h4>In a prospective, cross sectional, pilot study we assessed intestinal permeability in 35 IgAN patients, 18 patients with non-IgAN glomerulonephritides (GNs) and 19 healthy controls. After an overnight fast, trial participants ingested a multi-sugar solution and samples were obtained from 0 to 2, 2 to 5- and 5 to 24-h urine portions. Urinary sugar concentrations were quantified using isocratic ion-exchange high performance liquid chromatography. Indices of small intestinal permeability (0-2-h lactulose/L-rhamnose (L/R) ratio), distal small intestinal and proximal colonic permeability (2-5-h sucralos2023-01-01T00:00:00Z2023 Mar2025-04-04T14:17:02.85Z2025-02-19T02:23:03.278ZS-EPMC99985623610736910.1007/s40620-022-01454-2