biostudies-literatureUnknown14Zhou Y<h4>Objective</h4>Major depressive disorder (MDD) is associated with suicidal attempts (SAs) among adolescents, with suicide being the most common cause of mortality in this age group. This study explored the predictive utility of support vector machine (SVM)-based analyses of amplitude of low-frequency fluctuation (ALFF) results as a neuroimaging biomarker for aiding the diagnosis of MDD with SA in adolescents.<h4>Methods</h4>Resting-state functional magnetic resonance imaging (rs-fMRI) analyses of 71 first-episode, drug-naive adolescent MDD patients with SA and 54 healthy control individuals were conducted. ALFF and SVM methods were used to analyze the imaging data.<h4>Results</h4>Relative to healthy control individuals, adolescent MDD patients with a history of SAs showed reduced ALFF vFrontiers in psychology1146944https://www.ebi.ac.uk/biostudies/studies/S-EPMC9998935biostudies-literatureAbnormal amplitude of low-frequency fluctuation values as a neuroimaging biomarker for major depressive disorder with suicidal attempts in adolescents: A resting-state fMRI and support vector machine analysis.PMC9998935Chen MYan SZhou YChen CLiu TSong YfalseAbnormal amplitude of low-frequency fluctuation values as a neuroimaging biomarker for major depressive disorder with suicidal attempts in adolescents: A resting-state fMRI and support vector machine analysis.<h4>Objective</h4>Major depressive disorder (MDD) is associated with suicidal attempts (SAs) among adolescents, with suicide being the most common cause of mortality in this age group. This study explored the predictive utility of support vector machine (SVM)-based analyses of amplitude of low-frequency fluctuation (ALFF) results as a neuroimaging biomarker for aiding the diagnosis of MDD with SA in adolescents.<h4>Methods</h4>Resting-state functional magnetic resonance imaging (rs-fMRI) analyses of 71 first-episode, drug-naive adolescent MDD patients with SA and 54 healthy control individuals were conducted. ALFF and SVM methods were used to analyze the imaging data.<h4>Results</h4>Relative to healthy control individuals, adolescent MDD patients with a history of SAs showed reduced ALFF v2023-01-01T00:00:00Z20232025-04-04T18:50:10.092Z2025-04-04T18:50:10.092ZS-EPMC99989353691074210.3389/fpsyg.2023.1146944