{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Krishna Kumar Tiwari"],"journal":["Clinical cancer research : an official journal of the American Association for Cancer Research"],"pagination":["4213-4218"],"species":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/MODEL0911120001"],"repository":["biostudies-other"],"additional_accession":["18594002"],"pubmed_authors":["Krishna Kumar Tiwari","Nick Holford","Eléa Thibault-Greugny","Lucian Smith"]},"is_claimable":false,"name":"Tham2008 - PDmodel, Tumour shrinkage by gemcitabine and carboplatin","description":"

PURPOSE: This tumor response pharmacodynamic model aims to describe primary lesion shrinkage in non-small cell lung cancer over time and determine if concentration-based exposure metrics for gemcitabine or that of its metabolites,n2',2'-difluorodeoxyuridine or gemcitabine triphosphate, are better than gemcitabine dose for prediction of individual response. EXPERIMENTAL DESIGN: Gemcitabine was given thrice weekly on days 1 and 8 in combination with carboplatin, which was given only on day 1 of every cycle. Gemcitabine amount in the body and area under the concentration-time curves of plasma gemcitabine, 2',2'-difluorodeoxyuridine, and intracellular gemcitabine triphosphate in white cells were compared to determine which best describes tumor shrinkage over time. Tumor growth kinetics were described using a Gompertz-like model.RESULTS: The apparent half-life for the effect of gemcitabine was 7.67 weeks. The tumor turnover time constant was 21.8 week.cm. Baseline tumor size and gemcitabine amount in the body to attain 50% of tumor shrinkage were estimated to be 6.66 cm and 10,600 mg. There was no evidence of relapse during treatment.

","dates":{"release":"2009-11-15T00:00:00Z","modification":"2025-07-15T10:11:48.897Z","creation":"2025-03-29T10:05:19.338Z"},"accession":"MODEL0911120001","cross_references":{"biomodels___db":["BIOMD0000000234"],"pubmed":["18594002"],"mamo":["MAMO_0000046"],"go":["GO:0002357"],"doid":["DOID:1324"],"taxonomy":["9606"]}}