biostudies-otherUnknown5Audald Lloret i VillasPloS onee15176Homo sapienshttps://www.ebi.ac.uk/biostudies/studies/MODEL1409240001biostudies-other21179474Audald Lloret i VillasfalsePuri2010 - Mathematical Modeling for the Pathogenesis of Alzheimer's Disease<notes xmlns="http://www.sbml.org/sbml/level2/version4"> <body xmlns="http://www.w3.org/1999/xhtml"> <div class="dc:title">Puri2010 - Mathematical Modeling for thePathogenesis of Alzheimer's Disease</div><div class="dc:description"> <div>Puri2010 - Mathematical Modeling for the Pathogenesis of Alzheimer's Disease</div> <div> <br /> </div> <div>Encoded non-curated model. Issues:</div> <div> <br /> </div> <div>- Confusing replacement of <span style="color: rgb(84, 84, 84); font-family: arial, sans-serif; font-size: small; line-height: 18px;">α</span>16 when t = 3 years</div> <div>- Confusing 4th rate equation</div></div><div class="dc:bibliographicCitation"> <p>This model is described in the article:</p> <div class="bibo:title"> <a href="http://identifiers.org/pubmed/21179474" title="Access to this publication">Mathematical modeling for the pathogenesis of Alzheimer's disease.</a> </div> <div class="bibo:authorList">Puri IK, Li L.</div> <div class="bibo:Journal">PLoS ONE 2010; 5(12): e15176</div> <p>Abstract:</p> <div class="bibo:abstract"> <p>Despite extensive research, the pathogenesis of neurodegenerative Alzheimer's disease (AD) still eludes our comprehension. This is largely due to complex and dynamic cross-talks that occur among multiple cell types throughout the aging process. We present a mathematical model that helps define critical components of AD pathogenesis based on differential rate equations that represent the known cross-talks involving microglia, astroglia, neurons, and amyloid-? (A?). We demonstrate that the inflammatory activation of microglia serves as a key node for progressive neurodegeneration. Our analysis reveals that targeting microglia may hold potential promise in the prevention and treatment of AD.</p> </div></div><div class="dc:publisher"> <p>This model is hosted on <a href="http://www.ebi.ac.uk/biomodels/">BioModels Database</a> and identified by: <a href="http://identifiers.org/biomodels.db/MODEL1409240001">MODEL1409240001</a>.</p> <p>To cite BioModels Database, please use: <a href="http://identifiers.org/pubmed/20587024" title="Latest BioModels Database publication">BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models</a>.</p></div><div class="dc:license"> <p>To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to <a href="http://creativecommons.org/publicdomain/zero/1.0/" title="Access to: CC0 1.0 Universal (CC0 1.0), Public Domain Dedication">CC0 Public Domain Dedication</a> for more information.</p></div></body> </notes>2014-09-24T00:00:00Z2025-07-15T09:19:44.348Z2025-03-30T21:42:31.892ZMODEL140924000121179474MAMO_0000046GO:0050729GO:0014008DOID:10652CL:0000127CL:0000129CL:00005409606P05067