biostudies-otherUnknown30Lucian SmithMathematical medicine and biology : a journal of the IMA311-337Homo sapienshttps://www.ebi.ac.uk/biostudies/studies/MODEL1409250001biostudies-other23002057Vincent Knight-SchrijverLucian SmithfalseBaker2013 - Cytokine Mediated Inflammation in Rheumatoid Arthritis - Age Dependent<notes xmlns="http://www.sbml.org/sbml/level2/version4"> <body xmlns="http://www.w3.org/1999/xhtml"> <div class="dc:title">Baker2013 - Cytokine Mediated Inflammation inRheumatoid Arthritis - Age Dependant</div><div class="dc:description">This model by Baker M. 2013, describesthe interaction between pro and anti-inflammatory cytokinesignalling in rheumatoid arthritis.<br /><br />Using two ordinary differential equations, the first model <a href="http://www.ebi.ac.uk/biomodels-main/anno-model-view.do?mid=BIOMD0000000550">[BIOMD0000000550]</a>analyses bifurcation and describes different pathological states byaltering inflammatory regulation parameters.<br />The second model <a href="http://www.ebi.ac.uk/biomodels-main/anno-model-view.do?mid=BIOMD0000000549">[BIOMD0000000549]</a>includes the effect that ageing has on pro-inflammatory signalling,allowing for time-dependant properties and disease progression tobe observed. The author also describes potential dosing forreversal of the disease state.</div><div class="dc:bibliographicCitation"> <p>This model is described in the article:</p> <div class="bibo:title"> <a href="http://identifiers.org/pubmed/23002057" title="Access to this publication">Mathematical modelling of cytokine-mediated inflammation in rheumatoid arthritis.</a> </div> <div class="bibo:authorList">Baker M, Denman-Johnson S, Brook BS, Gaywood I, Owen MR.</div> <div class="bibo:Journal">Math Med Biol 2013 Dec; 30(4): 311-337</div> <p>Abstract:</p> <div class="bibo:abstract"> <p>Rheumatoid arthritis (RA) is a chronic inflammatory disease preferentially affecting the joints and leading, if untreated, to progressive joint damage and disability. Cytokines, a group of small inducible proteins, which act as intercellular messengers, are key regulators of the inflammation that characterizes RA. They can be classified into pro-inflammatory and anti-inflammatory groups. Numerous cytokines have been implicated in the regulation of RA with complex up and down regulatory interactions. This paper considers a two-variable model for the interactions between pro-inflammatory and anti-inflammatory cytokines, and demonstrates that mathematical modelling may be used to investigate the involvement of cytokines in the disease process. The model displays a range of possible behaviours, such as bistability and oscillations, which are strongly reminiscent of the behaviour of RA e.g. genetic susceptibility and remitting-relapsing disease. We also show that the dose regimen as well as the dose level are important factors in RA treatments.</p> </div></div><div class="dc:publisher"> <p>This model is hosted on <a href="http://www.ebi.ac.uk/biomodels/">BioModels Database</a> and identified by: <a href="http://identifiers.org/biomodels.db/BIOMD0000000549">BIOMD0000000549</a>.</p> <p>To cite BioModels Database, please use: <a href="http://identifiers.org/pubmed/20587024" title="Latest BioModels Database publication">BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models</a>.</p></div><div class="dc:license"> <p>To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to <a href="http://creativecommons.org/publicdomain/zero/1.0/" title="Access to: CC0 1.0 Universal (CC0 1.0), Public Domain Dedication">CC0 Public Domain Dedication</a> for more information.</p></div></body> </notes>2014-09-25T00:00:00Z2025-07-15T10:01:20.225Z2025-03-29T13:32:23.777ZMODEL1409250001BIOMD000000054923002057REACT_75790CHEBI:67079MAMO_0000046GO:0019221GO:0050727PATO:0002104DOID:71489606FMA:84050BTO:0001823