biostudies-otherUnknown9Lucian SmithMolecular systems biology650Arabidopsis thalianahttps://www.ebi.ac.uk/biostudies/studies/MODEL1410030000biostudies-other23511208Andrew J MillarLucian SmithfalseGould2013 - Temperature Sensitive Circadian Clock<notes xmlns="http://www.sbml.org/sbml/level2/version4"> <body xmlns="http://www.w3.org/1999/xhtml"> <div class="dc:title">Gould2011 - Temperature Sensitive CircadianClock</div><div class="dc:description">This model is a temperature sensitiveversion of Pokhilko <i>et al</i>. 2010 (PMID:<a href="http://europepmc.org/abstract/MED/20865009">20865009</a>),which is <a href="http://www.ebi.ac.uk/biomodels-main/BIOMD0000000273">BIOMD0000000273</a>in BioModels.<br /></div><div class="dc:bibliographicCitation"> <p>This model is described in the article:</p> <div class="bibo:title"> <a href="http://identifiers.org/pubmed/23511208" title="Access to this publication">Network balance via CRY signalling controls the Arabidopsis circadian clock over ambient temperatures.</a> </div> <div class="bibo:authorList">Gould PD, Ugarte N, Domijan M, Costa M, Foreman J, Macgregor D, Rose K, Griffiths J, Millar AJ, Finkenstädt B, Penfield S, Rand DA, Halliday KJ, Hall AJ.</div> <div class="bibo:Journal">Mol. Syst. Biol. 2013; 9: 650</div> <p>Abstract:</p> <div class="bibo:abstract"> <p>Circadian clocks exhibit 'temperature compensation', meaning that they show only small changes in period over a broad temperature range. Several clock genes have been implicated in the temperature-dependent control of period in Arabidopsis. We show that blue light is essential for this, suggesting that the effects of light and temperature interact or converge upon common targets in the circadian clock. Our data demonstrate that two cryptochrome photoreceptors differentially control circadian period and sustain rhythmicity across the physiological temperature range. In order to test the hypothesis that the targets of light regulation are sufficient to mediate temperature compensation, we constructed a temperature-compensated clock model by adding passive temperature effects into only the light-sensitive processes in the model. Remarkably, this model was not only capable of full temperature compensation and consistent with mRNA profiles across a temperature range, but also predicted the temperature-dependent change in the level of LATE ELONGATED HYPOCOTYL, a key clock protein. Our analysis provides a systems-level understanding of period control in the plant circadian oscillator.</p> </div></div><div class="dc:publisher"> <p>This model is hosted on <a href="http://www.ebi.ac.uk/biomodels/">BioModels Database</a> and identified by: <a href="http://identifiers.org/biomodels.db/BIOMD0000000564">BIOMD0000000564</a>.</p> <p>To cite BioModels Database, please use: <a href="http://identifiers.org/pubmed/20587024" title="Latest BioModels Database publication">BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models</a>.</p></div><div class="dc:license"> <p>To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to <a href="http://creativecommons.org/publicdomain/zero/1.0/" title="Access to: CC0 1.0 Universal (CC0 1.0), Public Domain Dedication">CC0 Public Domain Dedication</a> for more information.</p></div></body> </notes>2014-10-03T00:00:00Z2025-07-15T10:00:48.395Z2025-03-29T17:55:23.005ZMODEL1410030000BIOMD0000000273BIOMD000000056423511208C00046MOD:00000CHEBI:35222CHEBI:36080CHEBI:33699MAMO_0000046GO:0005623GO:0009299GO:0006461GO:0030163GO:0006464GO:0006402GO:0007623GO:00064123702Q8L500P92973Q93WK5Q9LKL2Q6R0H1Q94BT6Q9SQI2