biostudies-otherUnknown110Lucian SmithProceedings of the National Academy of Sciences of the United States of AmericaE2934-43Homo sapienshttps://www.ebi.ac.uk/biostudies/studies/MODEL1410300001biostudies-other23847209Dirk FeyLucian SmithfalseReiterer2013 - pseudophosphatase STYX role in ERK signalling<notes xmlns="http://www.sbml.org/sbml/level2/version4"> <body xmlns="http://www.w3.org/1999/xhtml"> <div class="dc:title">Reiterer2013 - pseudophosphatase STYX role inERK signalling</div><div class="dc:bibliographicCitation"> <p>This model is described in the article:</p> <div class="bibo:title"> <a href="http://identifiers.org/pubmed/23847209" title="Access to this publication">Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2.</a> </div> <div class="bibo:authorList">Reiterer V, Fey D, Kolch W, Kholodenko BN, Farhan H.</div> <div class="bibo:Journal">Proc. Natl. Acad. Sci. U.S.A. 2013 Jul; 110(31): E2934-43</div> <p>Abstract:</p> <div class="bibo:abstract"> <p>Serine/threonine/tyrosine-interacting protein (STYX) is a catalytically inactive member of the dual-specificity phosphatases (DUSPs) family. Whereas the role of DUSPs in cellular signaling is well explored, the function of STYX is still unknown. Here, we identify STYX as a spatial regulator of ERK signaling. We used predictive-model simulation to test several hypotheses for possible modes of STYX action. We show that STYX localizes to the nucleus, competes with nuclear DUSP4 for binding to ERK, and acts as a nuclear anchor that regulates ERK nuclear export. Depletion of STYX increases ERK activity in both cytosol and nucleus. Importantly, depletion of STYX causes an ERK-dependent fragmentation of the Golgi apparatus and inhibits Golgi polarization and directional cell migration. Finally, we show that overexpression of STYX reduces ERK1/2 activation, thereby blocking PC12 cell differentiation. Overall, our results identify STYX as an important regulator of ERK1/2 signaling critical for cell migration and PC12 cell differentiation.</p> </div></div><div class="dc:publisher"> <p>This model is hosted on <a href="http://www.ebi.ac.uk/biomodels/">BioModels Database</a> and identified by: <a href="http://identifiers.org/biomodels.db/BIOMD0000000557">BIOMD0000000557</a>.</p> <p>To cite BioModels Database, please use: <a href="http://identifiers.org/pubmed/20587024" title="Latest BioModels Database publication">BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models</a>.</p></div><div class="dc:license"> <p>To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to <a href="http://creativecommons.org/publicdomain/zero/1.0/" title="Access to: CC0 1.0 Universal (CC0 1.0), Public Domain Dedication">CC0 Public Domain Dedication</a> for more information.</p></div></body> </notes>2014-10-30T00:00:00Z2025-07-15T10:01:06.215Z2025-03-29T17:53:35.59ZMODEL1410300001BIOMD000000055723847209MAMO_0000046GO:0070372GO:0005634GO:00058299606BTO:0000567Q13115P27361Q02750Q8WUJ0