biostudies-otherUnknown63Lucian SmithIEEE transactions on bio-medical engineering2047-2055https://www.ebi.ac.uk/biostudies/studies/MODEL1603110003biostudies-other27076052Mohammad Umer Sharif ShohanAalap VermaLucian SmithfalseVerma2016 - Ca(2+) Signal Propagation Along Hepatocyte Cords<notes xmlns="http://www.sbml.org/sbml/level2/version4"> <body xmlns="http://www.w3.org/1999/xhtml"> <div class="dc:title">Verma2016 - Ca(2+) Signal Propagation Along Hepatocyte Cords</div> <div class="dc:bibliographicCitation"> <p>This model is described in the article:</p> <div class="bibo:title"> <a href="http://identifiers.org/pubmed/27076052" title="Access to this publication">Computational Modeling of Spatiotemporal Ca(2+) Signal Propagation Along Hepatocyte Cords.</a> </div> <div class="bibo:authorList">Verma A, Makadia H, Hoek JB, Ogunnaike BA, Vadigepalli R.</div> <div class="bibo:Journal">IEEE Trans Biomed Eng 2016 Oct; 63(10): 2047-2055</div> <p>Abstract:</p> <div class="bibo:abstract"> <p>The purpose of this study is to model the dynamics of lobular Ca(2+) wave propagation induced by an extracellular stimulus, and to analyze the effect of spatially systematic variations in cell-intrinsic signaling parameters on sinusoidal Ca(2+) response.We developed a computational model of lobular scale Ca(2+) signaling that accounts for receptor- mediated initiation of cell-intrinsic Ca(2+) signal in hepatocytes and its propagation to neighboring hepatocytes through gap junction-mediated molecular exchange.Analysis of the simulations showed that a pericentral-to-periportal spatial gradient in hormone sensitivity and/or rates of IP3 synthesis underlies the Ca(2+) wave propagation. We simulated specific cases corresponding to localized disruptions in the graded pattern of these parameters along a hepatic sinusoid. Simulations incorporating locally altered parameters exhibited Ca(2+) waves that do not propagate throughout the hepatic plate. Increased gap junction coupling restored normal Ca(2+) wave propagation when hepatocytes with low Ca(2+) signaling ability were localized in the midlobular or the pericentral region.Multiple spatial patterns in intracellular signaling parameters can lead to Ca(2+) wave propagation that is consistent with the experimentally observed spatial patterns of Ca(2+) dynamics. Based on simulations and analysis, we predict that increased gap junction-mediated intercellular coupling can induce robust Ca(2+) signals in otherwise poorly responsive hepatocytes, at least partly restoring the sinusoidally oriented Ca (2+) waves.Our bottom-up model of agonist-evoked spatial Ca(2+) patterns can be integrated with detailed descriptions of liver histology to study Ca(2+) regulation at the tissue level.</p> </div> </div> <div class="dc:publisher"> <p>This model is hosted on <a href="http://www.ebi.ac.uk/biomodels/">BioModels Database</a> and identified by: <a href="http://identifiers.org/biomodels.db/MODEL1603110003">MODEL1603110003</a>.</p> <p>To cite BioModels Database, please use: <a href="http://identifiers.org/pubmed/20587024" title="Latest BioModels Database publication">BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models</a>.</p> </div> <div class="dc:license"> <p>To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to <a href="http://creativecommons.org/publicdomain/zero/1.0/" title="Access to: CC0 1.0 Universal (CC0 1.0), Public Domain Dedication">CC0 Public Domain Dedication</a> for more information.</p> </div> </body> </notes>2016-03-11T00:00:00Z2025-07-15T09:50:07.109Z2025-03-29T21:45:22.829ZMODEL1603110003BIOMD000000083427076052C00076NewIDMAMO_0000046GO:00197229606BTO:0000575P29995P30560