{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Anu G Nair"],"journal":["PLoS computational biology"],"pagination":["e1005080"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/MODEL1603270000"],"repository":["biostudies-other"],"additional_accession":["27584878"],"pubmed_authors":["Anu G Nair","Rahuman S Malik-Sheriff"]},"is_claimable":false,"name":"D1 LTP time window","description":"
Nair2016 - Integration of calcium anddopamine signals by D1R-expressing medium-sized spiny neurons

This model is described in the article:

Role of DARPP-32 and ARPP-21 in the Emergence of Temporal Constraints on Striatal Calcium and Dopamine Integration.
Nair AG, Bhalla US, Hellgren Kotaleski J.
PLoS Comput. Biol. 2016 Sep; 12(9): e1005080

Abstract:

In reward learning, the integration of NMDA-dependent calcium and dopamine by striatal projection neurons leads to potentiation of corticostriatal synapses through CaMKII/PP1 signaling. In order to elicit the CaMKII/PP1-dependent response, the calcium and dopamine inputs should arrive in temporal proximity and must follow a specific (dopamine after calcium) order. However, little is known about the cellular mechanism which enforces these temporal constraints on the signal integration. In this computational study, we propose that these temporal requirements emerge as a result of the coordinated signaling via two striatal phosphoproteins, DARPP-32 and ARPP-21. Specifically, DARPP-32-mediated signaling could implement an input-interval dependent gating function, via transient PP1 inhibition, thus enforcing the requirement for temporal proximity. Furthermore, ARPP-21 signaling could impose the additional input-order requirement of calcium and dopamine, due to its Ca2+/calmodulin sequestering property when dopamine arrives first. This highlights the possible role of phosphoproteins in the temporal aspects of striatal signal transduction.

This model is hosted on BioModels Database and identified by: MODEL1603270000.

To cite BioModels Database, please use: Chelliah V et al. BioModels: ten-year anniversary. Nucl. Acids Res. 2015, 43(Database issue):D542-8.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

","dates":{"release":"2016-03-27T00:00:00Z","modification":"2025-07-15T09:03:14.704Z","creation":"2025-03-30T22:24:48.663Z"},"accession":"MODEL1603270000","cross_references":{"pubmed":["27584878"],"mamo":["MAMO_0000046"]}}