biostudies-otherUnknown12Lucian SmithPloS onee0187568https://www.ebi.ac.uk/biostudies/studies/MODEL1610100004biostudies-other29095952Mohammad Umer Sharif ShohanLucian SmithCarole ProctorfalseProctor2017- Role of microRNAs in osteoarthritis (Positive Feedforward Incoherent By MicroRNA)_1<notes xmlns="http://www.sbml.org/sbml/level2/version4"> <body xmlns="http://www.w3.org/1999/xhtml"> <div class="dc:title">Proctor2017- Role of microRNAs inosteoarthritis (Positive Feedforward Incoherent By MicroRNA)</div> <div class="dc:bibliographicCitation"> <p>This model is described in the article:</p> <div class="bibo:title"> <a href="http://identifiers.org/pubmed/29095952" title="Access to this publication">Computer simulation models as a tool to investigate the role of microRNAs in osteoarthritis.</a> </div> <div class="bibo:authorList">Proctor CJ, Smith GR.</div> <div class="bibo:Journal">PLoS ONE 2017; 12(11): e0187568</div> <p>Abstract:</p> <div class="bibo:abstract"> <p>The aim of this study was to show how computational models can be used to increase our understanding of the role of microRNAs in osteoarthritis (OA) using miR-140 as an example. Bioinformatics analysis and experimental results from the literature were used to create and calibrate models of gene regulatory networks in OA involving miR-140 along with key regulators such as NF-?B, SMAD3, and RUNX2. The individual models were created with the modelling standard, Systems Biology Markup Language, and integrated to examine the overall effect of miR-140 on cartilage homeostasis. Down-regulation of miR-140 may have either detrimental or protective effects for cartilage, indicating that the role of miR-140 is complex. Studies of individual networks in isolation may therefore lead to different conclusions. This indicated the need to combine the five chosen individual networks involving miR-140 into an integrated model. This model suggests that the overall effect of miR-140 is to change the response to an IL-1 stimulus from a prolonged increase in matrix degrading enzymes to a pulse-like response so that cartilage degradation is temporary. Our current model can easily be modified and extended as more experimental data become available about the role of miR-140 in OA. In addition, networks of other microRNAs that are important in OA could be incorporated. A fully integrated model could not only aid our understanding of the mechanisms of microRNAs in ageing cartilage but could also provide a useful tool to investigate the effect of potential interventions to prevent cartilage loss.</p> </div> </div> <div class="dc:publisher"> <p>This model is hosted on <a href="http://www.ebi.ac.uk/biomodels/">BioModels Database</a> and identified by: <a href="http://identifiers.org/biomodels.db/MODEL1610100004">MODEL1610100004</a>.</p> <p>To cite BioModels Database, please use: <a href="http://identifiers.org/pubmed/25414348" target="_blank">Chelliah V et al. BioModels: ten-year anniversary. Nucl. Acids Res. 2015, 43(Database issue):D542-8</a>.</p> </div> <div class="dc:license"> <p>To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to <a href="http://creativecommons.org/publicdomain/zero/1.0/" title="Access to: CC0 1.0 Universal (CC0 1.0), Public Domain Dedication">CC0 Public Domain Dedication</a> for more information.</p> </div> </body> </notes>2016-10-10T00:00:00Z2025-07-15T09:49:21.491Z2025-03-29T21:57:53.485ZMODEL1610100004BIOMD000000086029095952C17207NCIT:C25966MAMO_00000469606