biostudies-otherUnknown114samuel CollombetProceedings of the National Academy of Sciences of the United States of America5792-5799https://www.ebi.ac.uk/biostudies/studies/MODEL1610240000biostudies-other28584084samuel CollombetfalseCollombet2016 - Lymphoid and myeloid cell specification and transdifferentiation<notes xmlns="http://www.sbml.org/sbml/level3/version1/core"> <body xmlns="http://www.w3.org/1999/xhtml"> <div class="dc:title">Collombet2016 - Lymphoid and myeloid cellspecification and transdifferentiation</div><div class="dc:bibliographicCitation"> <p>This model is described in the article:</p> <div class="bibo:title"> <a href="http://identifiers.org/doi/10.1073/pnas.1610622114" title="Access to this publication">Logical modeling of lymphoid and myeloid cell specification and transdifferentiation</a> </div> <div class="bibo:authorList">Samuel Collombet, Chris van Oevelen, Jose Luis Sardina Ortega, Wassim Abou-Jaoudé, Bruno Di Stefano, Morgane Thomas-Chollier, Thomas Graf, and Denis Thieffry</div> <div class="bibo:Journal">Proceedings of the National Academy of Sciences of the United States of America</div> <p>Abstract:</p> <div class="bibo:abstract"> <p>Blood cells are derived from a common set of hematopoietic stem cells, which differentiate into more specific progenitors of the myeloid and lymphoid lineages, ultimately leading to differentiated cells. This developmental process is controlled by a complex regulatory network involving cytokines and their receptors, transcription factors, and chromatin remodelers. Using public data and data from our own molecular genetic experiments (quantitative PCR, Western blot, EMSA) or genome-wide assays (RNA-sequencing, ChIP-sequencing), we have assembled a comprehensive regulatory network encompassing the main transcription factors and signaling components involved in myeloid and lymphoid development. Focusing on B-cell and macrophage development, we defined a qualitative dynamical model recapitulating cytokine-induced differentiation of common progenitors, the effect of various reported gene knockdowns, and the reprogramming of pre-B cells into macrophages induced by the ectopic expression of specific transcription factors. The resulting network model can be used as a template for the integration of new hematopoietic differentiation and transdifferentiation data to foster our understanding of lymphoid/myeloid cell-fate decisions.</p> </div></div><div class="dc:publisher"> <p>This model is hosted on <a href="http://www.ebi.ac.uk/biomodels/">BioModels Database</a> and identified by: <a href="http://identifiers.org/biomodels.db/MODEL1610240000">MODEL1610240000</a>.</p> <p>To cite BioModels Database, please use: <a href="http://identifiers.org/pubmed/20587024" title="Latest BioModels Database publication">BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models</a>.</p></div><div class="dc:license"> <p>To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to <a href="http://creativecommons.org/publicdomain/zero/1.0/" title="Access to: CC0 1.0 Universal (CC0 1.0), Public Domain Dedication">CC0 Public Domain Dedication</a> for more information.</p></div></body> </notes>2016-10-24T00:00:00Z2025-07-14T17:55:51.926Z2025-03-30T22:38:35.152ZMODEL161024000028584084MAMO_0000030