biostudies-otherUnknown36Lucian SmithThe EMBO journal2161-2176Homo sapienshttps://www.ebi.ac.uk/biostudies/studies/MODEL1704030000biostudies-other28607002Lucian SmithKaren AkopyanfalseJaiswal2017 - Cell cycle arrest<notes xmlns="http://www.sbml.org/sbml/level3/version1/core"> <body xmlns="http://www.w3.org/1999/xhtml"> <div class="dc:title">Jaiswal2017 - Cell cycle arrest</div><div class="dc:bibliographicCitation"> <p>This model is described in the article:</p> <div class="bibo:title"> <a href="http://identifiers.org/pubmed/28607002" title="Access to this publication">ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration.</a> </div> <div class="bibo:authorList">Jaiswal H, Benada J, Müllers E, Akopyan K, Burdova K, Koolmeister T, Helleday T, Medema RH, Macurek L, Lindqvist A.</div> <div class="bibo:Journal">EMBO J. 2017 Jul; 36(14): 2161-2176</div> <p>Abstract:</p> <div class="bibo:abstract"> <p>After DNA damage, the cell cycle is arrested to avoid propagation of mutations. Arrest in G2 phase is initiated by ATM-/ATR-dependent signaling that inhibits mitosis-promoting kinases such as Plk1. At the same time, Plk1 can counteract ATR-dependent signaling and is required for eventual resumption of the cell cycle. However, what determines when Plk1 activity can resume remains unclear. Here, we use FRET-based reporters to show that a global spread of ATM activity on chromatin and phosphorylation of ATM targets including KAP1 control Plk1 re-activation. These phosphorylations are rapidly counteracted by the chromatin-bound phosphatase Wip1, allowing cell cycle restart despite persistent ATM activity present at DNA lesions. Combining experimental data and mathematical modeling, we propose a model for how the minimal duration of cell cycle arrest is controlled. Our model shows how cell cycle restart can occur before completion of DNA repair and suggests a mechanism for checkpoint adaptation in human cells.</p> </div></div><div class="dc:publisher"> <p>This model is hosted on <a href="http://www.ebi.ac.uk/biomodels/">BioModels Database</a> and identified by: <a href="http://identifiers.org/biomodels.db/BIOMD0000000641">BIOMD0000000641</a>.</p> <p>To cite BioModels Database, please use: <a href="http://identifiers.org/pubmed/20587024" title="Latest BioModels Database publication">BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models</a>.</p></div><div class="dc:license"> <p>To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to <a href="http://creativecommons.org/publicdomain/zero/1.0/" title="Access to: CC0 1.0 Universal (CC0 1.0), Public Domain Dedication">CC0 Public Domain Dedication</a> for more information.</p></div></body> </notes>2017-04-03T00:00:00Z2025-07-15T09:57:28.452Z2025-03-29T18:18:09.702ZMODEL1704030000BIOMD000000064128607002MAMO_0000046PW:0001362GO:0007095GO:0005634GO:0042769GO:0000724GO:00063039606BTO:0004910Q13315P53350Q13535