biostudies-otherUnknown8Guido SantosFrontiers in cellular and infection microbiology159https://www.ebi.ac.uk/biostudies/studies/MODEL1805170001biostudies-other29868515Rahuman S Malik-SheriffGuido SantosfalseSantos2018 - Pneumococcal infection in alveoliMultiscale mathematical model of pneumococcal alveolar infection. This model analyses the role of cellular and molecular interactions during the first 10 h after alveolar invasion of Streptococcus pneumoniae bacteria. By “multi-level” we mean that we simulated the interplay between different temporal and spatial scales in a single computational model. In this instance, we included the intracellular scale of processes driving lung epithelial cell activation together with the scale of cell-to-cell interactions between bacteria and alveolar macrophages at the alveolar tissue. The model combines agent-based modelling and ODE modelling strategies. The original article of the article can be found in https://doi.org/10.3389/fcimb.2018.00159.2018-05-17T00:00:00Z2025-07-14T17:05:27.681Z2025-03-31T13:22:33.161ZMODEL180517000129868515