biostudies-otherUnknown8Lucian SmithCPT: pharmacometrics & systems pharmacology177-187Homo sapienshttps://www.ebi.ac.uk/biostudies/studies/MODEL1907240003biostudies-other30480383Lucian SmithJohannes MeyerfalseSchropp2019 - Target-Mediated Drug Disposition Model for Bispecific Antibodies<notes xmlns="http://www.sbml.org/sbml/level2/version4"> <body xmlns="http://www.w3.org/1999/xhtml"> <pre>This model presents a general target-mediated drug disposition (TMDD) model for bispecific antibodies (BsAbs), which bind to two different targets on different cell membranes. The model includes four different binding events for BsAbs, turnover of the targets, and internalization of the complexes. In addition, a quasi-equilibrium (QE) approximation with decreased number of binding parameters is also present.</pre> </body> </notes>2019-07-24T00:00:00Z2025-07-15T09:51:48.136Z2025-03-29T21:01:58.517ZMODEL1907240003BIOMD0000000788SBO:0000296SBO:000018030480383UBERON:0000479C28227C40536C1454C38299C18106C61559MAMO_0000046GO:0008015GO:0031623GO:0007588GO:00064129606BTO:0000131BTO:0000553MI:0914