{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22"],"submitter":["Lucian Smith"],"journal":["Pharmaceutical research"],"pagination":["1589-1596"],"species":["Unknown"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/MODEL1907290001"],"repository":["biostudies-other"],"additional_accession":["16180117"],"pubmed_authors":["Tung Nguyen","Lucian Smith","Johannes Meyer"]},"is_claimable":false,"name":"Mager2005 - Quasi-equilibrium pharmacokinetic model for drugs exhibiting target-mediated drug disposition","description":"

This model was developed with the aim of constructing an equilibrium model of the pharmacokinetic behaviour of a drug exhibiting target-mediated drug disposition (TMDD). TMDD involves the inclusion of drug-target interactions within a pharmacokinetic description, something which is usually considered negligible and subsequently excluded. Two approaches were used, one of which involved a quasi-equilibrium method to describe the kinetics of TMDD.

","dates":{"release":"2019-07-29T00:00:00Z","modification":"2025-07-15T09:52:43.936Z","creation":"2025-03-29T20:59:39.154Z"},"accession":"MODEL1907290001","cross_references":{"sbo":["SBO:0000177","SBO:0000180","SBO:0000179"],"biomodels___db":["BIOMD0000000765"],"pubmed":["16180117","11999290"],"ncit":["C79370","C16353","C15299","C12801","C18106"],"chebi":["CHEBI:23888"],"mamo":["MAMO_0000046"],"go":["GO:0043235","GO:0031623","GO:0006412"],"taxonomy":["1758"]}}