biostudies-otherUnknown22Lucian SmithPharmaceutical research1589-1596Unknownhttps://www.ebi.ac.uk/biostudies/studies/MODEL1907290001biostudies-other16180117Tung NguyenLucian SmithJohannes MeyerfalseMager2005 - Quasi-equilibrium pharmacokinetic model for drugs exhibiting target-mediated drug disposition<notes xmlns="http://www.sbml.org/sbml/level2/version4"> <body xmlns="http://www.w3.org/1999/xhtml"> <pre>This model was developed with the aim of constructing an equilibrium model of the pharmacokinetic behaviour of a drug exhibiting target-mediated drug disposition (TMDD). TMDD involves the inclusion of drug-target interactions within a pharmacokinetic description, something which is usually considered negligible and subsequently excluded. Two approaches were used, one of which involved a quasi-equilibrium method to describe the kinetics of TMDD.</pre> </body> </notes>2019-07-29T00:00:00Z2025-07-15T09:52:43.936Z2025-03-29T20:59:39.154ZMODEL1907290001SBO:0000177SBO:0000180SBO:0000179BIOMD00000007651618011711999290C79370C16353C15299C12801C18106CHEBI:23888MAMO_0000046GO:0043235GO:0031623GO:00064121758