{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Lucian Smith"],"journal":["Journal of Biological Systems"],"pagination":["51-80"],"species":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/MODEL2001200003"],"repository":["biostudies-other"],"additional_accession":["10.1142/S0218339008002435"],"pubmed_authors":["Mohammad Umer Sharif Shohan","Lucian Smith"]},"is_claimable":false,"name":"dePillis2008 - Optimal control of mixed immunotherapy and chemotherapy of tumors","description":"&amp;lt;notes xmlns=&amp;quot;http://www.sbml.org/sbml/level2/version4&amp;quot;&amp;gt;      &amp;lt;body xmlns=&amp;quot;http://www.w3.org/1999/xhtml&amp;quot;&amp;gt;        &amp;lt;pre&amp;gt;Optimal control of mixed immunotherapy and chemotherapy of tumorsLisette Depillis, K. R. Fister , W. Gu, Tiffany Head, Kenny Maples, Todd Neal, Anand Murugan and Kenji KozaiAbstractWe investigate a mathematical population model of tumor-immune interactions. Thepopulations involved are tumor cells, specific and non-specific immune cells, and con-centrations of therapeutic treatments. We establish the existence of an optimal con-trol for this model and provide necessary conditions for the optimal control triple forsimultaneous application of chemotherapy, tumor infiltrating lymphocyte (TIL) ther-apy, and interleukin-2 (IL-2) treatment. We discuss numerical results for the combina-tion of the chemo-immunotherapy regimens. We find that the qualitative nature of ourresults indicates that chemotherapy is the dominant intervention with TIL interactingin a complementary fashion with the chemotherapy. However, within the optimal con-trol context, the interleukin-2 treatment does not become activated for the estimatedparameter ranges.","dates":{"release":"2020-01-20T00:00:00Z","modification":"2025-07-15T09:47:51.24Z","creation":"2025-03-29T22:13:15.101Z"},"accession":"MODEL2001200003","cross_references":{"biomodels___db":["BIOMD0000000913","MODEL2001160001"],"ncit":["NCIT:C120462","C132890","C191"],"mamo":["MAMO_0000046"],"go":["GO:0002697","GO:0015893","GO:0070970","GO:0002418","GO:0045583","GO:0032663","GO:0072676","GO:0002252","GO:0046649","GO:0002355"],"taxonomy":["9606"],"bto":["BTO:0000289"],"uniprot":["P60568"],"doi":["10.1142/S0218339008002435"],"efo":["0000616"]}}