{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Ahmed Mobeen"],"journal":["Proteins: Structure, Function, and Bioinformatics"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/MODEL2001290001"],"repository":["biostudies-other"],"additional_accession":["10.1002/prot.26388"],"pubmed_authors":["Ahmed Mobeen"]},"is_claimable":false,"name":"AhmedMobeen2021 - NF-kB Activation Model","description":"NF-kappaB Activation Model includes the activation of both NFKB1:RELA and NFKB2:RELB for Canonical and Non-Canonical Pathway respectively.The model includes the pathway model integrated with post-translational modifications of NF-kB subunits that regulate the NFKB1:RELA and NFKB2:RELB activity. The processes that are regulated by NF-kB pathway can be monitored through following readouts NFKB1:RELA Activity, NFKB2:RELB Activity, Degraded RelA, Degraded RelB, Degraded IkB, Degraded NIK, Apoptosis, Tumour, Antiviral Activity, B Cell Growth and Cell Migration. However, last 5 processes above are also influenced by other pathways too, therefore while making predictions, caution has to be exercised.","dates":{"release":"2020-01-29T00:00:00Z","modification":"2025-07-14T17:44:51.346Z","creation":"2025-03-30T22:50:44.255Z"},"accession":"MODEL2001290001","cross_references":{"pubmed":["14755251","20639196","19479062","1568526","10395671","14651848","20610653","22435563","19448676","8752276","25082354","16603398","20966071","18710948","14560022","17397930","11781828","17562858","8887559","20383180","18575461","9597130","22829912","20110348","18927610","10894547","21113135","12808134","18263619","9687510","19339690","23746843","15775976","9150141","20182612","20622870","7628694","15963787","27744496","15084260","26311312","18040287","19643665","16622006","18362147","16964262","16410802","19933278","22031950","17702576","10893229","14762441","28086098","16154084","11430833","16300471","9742107","12563261","26999213","26592460","17468759","8657102","21242888","9223278","12419806","26505215","11485901","25497099","11035810","10364240","16023600","15858576","16105840","19917778","21173796","12972501","23806334","21098220","10733571","8608943","11520989","15743821","19258594","23243601","12419817","18456659","11865184","9020361","10648602","20816209","20538615","9343425","9724653","10581243","27929056","10485710","16862178","10582338","26385424","22152481","18035048","16192349","15870263","22649547","22265677","14556004","18304834","25631445","21621563","21904602","21127072","11239468","24675460","18453612","23202365","18439422","16751281","17673665","15140882","8306959","24432023","8601309","10485701","24726323","22842477","11992002","8756660","24726327","22511786","30223576","25614319","17462920","17785824","18617892","20410276","9416507","22205033","18045535","11591705","23459942","23453969","15152190","28939760","29435148","16306936","29610295","19911008","23365087","18988733","18053812","10490645","14580335","22864569","12473183","2527658","23453972","14617795","16906147","15105418","15258597","12871932","1604322","19197368","28190248","20562110","12374738","22879398","12692549","22520844","12871131","11390642","10521409","9660950","19683540","10935625","30391544","11375388","22435549","18353649","18997794","21538482","18997792","11129660","12855578","14563684","19864672","18362886","29983639","10102273","18984593","24442433","20604809","29199608","19746155","12840022","19262565","29149101","7615558","25986658","21515635","20080798","10102704","17982091","11160127","24519937","22685329","21616434","9133417","23032186","29139553","28122346","27552911","20932476","30571771","12671680","27942213","26195760","8710491","24555472","12628924","15125833","16547522","10783893","19646419","14690596","19776010","20501937","24611020","9430676","28753426","23691078","11839738","20457564","12709443","20682767","25590437","17692805","20603617","8599092","28722711","22773835","24008839","23334419","16893496","16684768","17457343","19426221","21217772","20188669","24656046","18588945","29797567","15465828","28712664","7744823","23023393","29742424","8749392","15489227","17720813","1732739","20507904","22081069","9576950","30390256","17254973","18462924","12773372","15210742","8550590","12482991","26291483","25355519","21131967","16135789","19440234","26082493","16497931","23250430","7510216","12547194","21777808","18391968","12048245","11867732","11027342","28626800","17540171","19131627","25063873","20652371","19270718","9520446","27187478","21765415","18620544","11916938","15642694","12133833","8837778","9045933","11983155","24890514","12515809","28416283","19854139","15073170","25116307","17012367","8496683","12939342","23904475","22244329","12091382","18212740","12389034","23343355","12764129","8710854","22244324","11994270","24061474","19609947","16125763","11238989","24616021","25451943","20300203","23180782","21862579","10469655","12881425","23708998","29037210","12887889","28298335","16203735","25187272","7690989","23832113","27140617","17237370","20086235","8681372","26042739","11090634","9789032","17633023","15485626","12387745","20961594","19359218","12947093","26170389","8649784","15084608","18391976","25267645","17100583","20304918","11262391","16056267","15878912","23813857","18391970","18779315","18347013","19345186"],"hgnc":["11935"],"mamo":["OTHER"],"uniprot":["Q15759","Q9NNX6","Q13547","P28482","O75676","Q9NQ31","Q9UHD2","O75582","P37231","Q9NYS0","Q99558","P17612","P68400","Q9Y297","P25963","P29965"],"doi":["10.1002/prot.26388"],"unknown":["null"]}}