biostudies-otherUnknownAhmed MobeenProteins: Structure, Function, and Bioinformaticshttps://www.ebi.ac.uk/biostudies/studies/MODEL2001290001biostudies-other10.1002/prot.26388Ahmed MobeenfalseAhmedMobeen2021 - NF-kB Activation ModelNF-kappaB Activation Model includes the activation of both NFKB1:RELA and NFKB2:RELB for Canonical and Non-Canonical Pathway respectively.The model includes the pathway model integrated with post-translational modifications of NF-kB subunits that regulate the NFKB1:RELA and NFKB2:RELB activity. The processes that are regulated by NF-kB pathway can be monitored through following readouts NFKB1:RELA Activity, NFKB2:RELB Activity, Degraded RelA, Degraded RelB, Degraded IkB, Degraded NIK, Apoptosis, Tumour, Antiviral Activity, B Cell Growth and Cell Migration. However, last 5 processes above are also influenced by other pathways too, therefore while making predictions, caution has to be exercised.2020-01-29T00:00:00Z2025-07-14T17:44:51.346Z2025-03-30T22:50:44.255ZMODEL20012900011475525120639196194790621568526103956711465184820610653224355631944867687522762508235416603398209660711871094814560022173979301178182817562858888755920383180185754619597130228299122011034818927610108945472111313512808134182636199687510193396902374684315775976915014120182612206228707628694159637872774449615084260263113121804028719643665166220061836214716964262164108021993327822031950177025761089322914762441280860981615408411430833163004719742107125632612699921326592460174687598657102212428889223278124198062650521511485901254970991103581010364240160236001585857616105840199177782117379612972501238063342109822010733571860894311520989157438211925859423243601124198171845665911865184902036110648602208162092053861593434259724653105812432792905610485710168621781058233826385424221524811803504816192349158702632264954722265677145560041830483425631445216215632190460221127072112394682467546018453612232023651843942216751281176736651514088283069592443202386013091048570124726323228424771199200287566602472632722511786302235762561431917462920177858241861789220410276941650722205033180455351159170523459942234539691515219028939760294351481630693629610295199110082336508718988733180538121049064514580335228645691247318325276582345397214617795169061471510541815258597128719321604322191973682819024820562110123747382287939812692549225208441287113111390642105214099660950196835401093562530391544113753882243554918353649189977942153848218997792111296601285557814563684198646721836288629983639101022731898459324442433206048092919960819746155128400221926256529149101761555825986658215156352008079810102704179820911116012724519937226853292161643491334172303218629139553281223462755291120932476305717711267168027942213261957608710491245554721262892415125833165475221078389319646419146905961977601020501937246110209430676287534262369107811839738204575641270944320682767255904371769280520603617859909228722711227738352400883923334419168934961668476817457343194262212121777220188669246560461858894529797567154658282871266477448232302339329742424874939215489227177208131732739205079042208106995769503039025617254973184629241277337215210742855059012482991262914832535551921131967161357891944023426082493164979312325043075102161254719421777808183919681204824511867732110273422862680017540171191316272506387320652371192707189520446271874782176541518620544119169381564269412133833883777890459331198315524890514125158092841628319854139150731702511630717012367849668312939342239044752224432912091382182127401238903423343355127641298710854222443241199427024061474196099471612576311238989246160212545194320300203231807822186257910469655128814252370899829037210128878892829833516203735251872727690989238321132714061717237370200862358681372260427391109063497890321763302315485626123877452096159419359218129470932617038986497841508460818391976252676451710058320304918112623911605626715878912238138571839197018779315183470131934518611935OTHERQ15759Q9NNX6Q13547P28482O75676Q9NQ31Q9UHD2O75582P37231Q9NYS0Q99558P17612P68400Q9Y297P25963P2996510.1002/prot.26388null