{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Shailza Singh"],"journal":["Frontiers in Genetics"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/MODEL2012040002"],"repository":["biostudies-other"],"additional_accession":["10.3389/fgene.2021.784664"],"pubmed_authors":["Rahuman S Malik-Sheriff","Shailza Singh"]},"is_claimable":false,"name":"Khandibharad2022 - IL-12 regulation by IL-10 in Leishmaniasis","description":"

In this model, TLR2-TLR6 mediates MyD88 pathway gets activated, which activates IL-12 production and induces iNOS expression when the Macrophage is infected with Leishmania parasite. The early induction of IL-10 takes place which leads to the induction of NFIL3, HDAC3, and SHP-1. They inhibit IL-12 production and thus hamper IL-12 induced IFN-gamma mediated; Nitric oxide production. A key transcription factor NFAT5 connects IL-12 and IL-10 pathways. It upregulates IL-12 and downregulates IL-10. In this model, NFAT5 is downregulated which is also inhibiting IL-12.

","dates":{"release":"2020-12-04T00:00:00Z","modification":"2025-07-14T17:41:08.744Z","creation":"2025-03-30T22:54:58.343Z"},"accession":"MODEL2012040002","cross_references":{"mamo":["MAMO_0000046"],"doi":["10.3389/fgene.2021.784664"]}}