biostudies-otherUnknown12Shailza SinghFrontiers in Geneticshttps://www.ebi.ac.uk/biostudies/studies/MODEL2012040002biostudies-other10.3389/fgene.2021.784664Rahuman S Malik-SheriffShailza SinghfalseKhandibharad2022 - IL-12 regulation by IL-10 in Leishmaniasis<notes xmlns="http://www.sbml.org/sbml/level2"> <body xmlns="http://www.w3.org/1999/xhtml"> <p>In this model, TLR2-TLR6 mediates MyD88 pathway gets activated, which activates IL-12 production and induces iNOS expression when the Macrophage is infected with Leishmania parasite. The early induction of IL-10 takes place which leads to the induction of NFIL3, HDAC3, and SHP-1. They inhibit IL-12 production and thus hamper IL-12 induced IFN-gamma mediated; Nitric oxide production. A key transcription factor NFAT5 connects IL-12 and IL-10 pathways. It upregulates IL-12 and downregulates IL-10. In this model, NFAT5 is downregulated which is also inhibiting IL-12.</p> </body> </notes>2020-12-04T00:00:00Z2025-07-14T17:41:08.744Z2025-03-30T22:54:58.343ZMODEL2012040002MAMO_000004610.3389/fgene.2021.784664