{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Lucian Smith"],"journal":["Scientific reports"],"pagination":["2696"],"species":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/MODEL2204290002"],"repository":["biostudies-other"],"additional_accession":["10.1038/s41598-018-20348-7"],"pubmed_authors":["Lucian Smith","Mikal Daou"]},"is_claimable":false,"name":"Jeon2018 - Enzyme clustering in Glucose metabolism","description":"Miji Jeon, Hye-Won Kang & Songon An. A Mathematical Model for Enzyme Clustering in Glucose Metabolism. Scientific Reports 8, 1 (2018).<p></p><p></p>We have recently demonstrated that the rate-limiting enzymes in human glucose metabolism organize into cytoplasmic clusters to form a multienzyme complex, the glucosome, in at least three different sizes. Quantitative high-content imaging data support a hypothesis that the glucosome clusters regulate the direction of glucose flux between energy metabolism and building block biosynthesis in a cluster size-dependent manner. However, direct measurement of their functional contributions to cellular metabolism at subcellular levels has remained challenging. In this work, we develop a mathematical model using a system of ordinary differential equations, in which the association of the rate-limiting enzymes into multienzyme complexes is included as an essential element. We then demonstrate that our mathematical model provides a quantitative principle to simulate glucose flux at both subcellular and population levels in human cancer cells. Lastly, we use the model to simulate 2-deoxyglucose-mediated alteration of glucose flux in a population level based on subcellular high-content imaging data. Collectively, we introduce a new mathematical model for human glucose metabolism, which promotes our understanding of functional roles of differently sized multienzyme complexes in both single-cell and population levels.","dates":{"release":"2022-04-29T00:00:00Z","modification":"2025-07-15T09:43:21.173Z","creation":"2025-03-29T22:32:12.749Z"},"accession":"MODEL2204290002","cross_references":{"sbo":["SBO:0000330","SBO:0000341","SBO:0000394","SBO:0000217","SBO:0000180","SBO:0000526","SBO:0000009"],"biomodels___db":["BIOMD0000001055"],"reactome":["R-HSA-70475","R-HSA-70471","R-HSA-71496"],"ncit":["C28597","C16981","NCIT:C21034"],"chebi":["CHEBI:30744","CHEBI:78697","CHEBI:17234","CHEBI:25212","CHEBI:15361","CHEBI:61304","CHEBI:18021","CHEBI:64297","CHEBI:78682"],"mamo":["MAMO_0000046"],"go":["GO:0004634","GO:0004611","GO:0006517","GO:0005737","GO:0004736","GO:0008152","GO:0004619","GO:0046323","GO:0016310","GO:0006006","GO:0016311"],"taxonomy":["9606"],"uniprot":["P30613","P08237","P35558","P09467"],"doi":["10.1038/s41598-018-20348-7"],"unknown":["null"]}}