{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["522"],"submitter":["Lucian Smith"],"journal":["Journal of theoretical biology"],"pagination":["110685"],"species":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/MODEL2205170001"],"repository":["biostudies-other"],"additional_accession":["10.1016/j.jtbi.2021.110685"],"pubmed_authors":["Lucian Smith","Mikal Daou"]},"is_claimable":false,"name":"Chulian2021 - feedback signalling in B lymphopoeisis","description":"Salvador Chulián, Álvaro Martínez-Rubio, Anna Marciniak-Czochra, Thomas Stiehl, Cristina Blázquez Goñi, Juan Francisco Rodríguez Gutiérrez, Manuel Ramírez Orellana, Ana Castillo Robleda, Víctor M. Pérez-García & María Rosa. Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach. Journal of Theoretical Biology 522 (2021).<p></p><p></p>Haematopoiesis is the process of generation of blood cells. Lymphopoiesis generates lymphocytes, the cells in charge of the adaptive immune response. Disruptions of this process are associated with diseases like leukaemia, which is especially incident in children. The characteristics of self-regulation of this process make them suitable for a mathematical study.<p></p><p></p>In this paper we develop mathematical model","dates":{"release":"2022-05-17T00:00:00Z","modification":"2025-07-15T09:43:19.495Z","creation":"2025-03-29T22:32:17.828Z"},"accession":"MODEL2205170001","cross_references":{"sbo":["SBO:0000001","SBO:0000153","SBO:0000393","SBO:0000280","SBO:0000169","C18314","C12434"],"biomodels___db":["BIOMD0000001056"],"ncit":["NCIT:C12474","NCIT:C33058","NCIT:C32766"],"mamo":["MAMO_0000046"],"go":["GO:0006955","GO:0030097"],"taxonomy":["9606"],"bto":["BTO:0000141"],"doi":["10.1016/j.jtbi.2021.110685"]}}