biostudies-otherUnknownHomo sapiens (human)https://www.ebi.ac.uk/biostudies/studies/S-BSST1128biostudies-otherfalseProgenitor-like LSCmed cells are enriched in the prostates of Pb-PRL mice, a preclinical model of benign prostate hyperplasiaThe prostate epithelium is made of basal and luminal cells. We recently identified in wild type mouse prostates a rare population of luminal progenitor-like cells that we called LSCmed according to their FACS profile (Lin-/Sca-1+/CD49fmed). LSCmed defines non-secretory luminal cells that exhibit a specific transcriptomic profile enriched in stemness markers (Psca, Tacstd2, Cd44, Sox2, Sca-1), and are able to generate organoids in vitro and glandular epithelium in vivo. Importantly, LSCmed cells are tolerant to androgen deprivation. Here we investigated the prevalence of these cells in probasin-prolactin (Pb-PRL) mice, a model of benign prostate hyperplasia (BPH). We show that LSCmed prevalence is increased from ± 5% of epithelial cells in the prostate of WT mice, to ± 20% of epithelial ce2023-09-12T00:00:00Z2023-09-13T07:11:46.723Z2023-06-22T07:32:08.77ZS-BSST1128