{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":[null],"species":["Homo sapiens (human)"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BSST1643"],"repository":["biostudies-other"],"additional_accession":[]},"is_claimable":false,"name":"Tertiary lymphoid structures in pancreatic cancer resemble lymphoid follicles in secondary lymphoid organs as common sites of anti-tumor adaptive immune responses","description":"Tertiary lymphoid structures (TLS) in cancer are considered ectopic hotspots for immune activation, which are similar to lymphoid follicles in secondary lymphoid organs (SLO). This study elucidates shared and TLS/SLO-specific features in pancreatic ductal adenocarcinoma (PDAC). TLS abundance was related to superior survival and T-cell abundance in 110 treatment-naïve PDAC samples, underlining their clinical relevance. Immunofluorescence microscopy identified structural homologies between TLS and SLO. In RNA-expression analyses of laser-microdissected TLS and paired SLOs, we observed largely overlapping expression patterns of immune-related gene clusters, but distinct expression patterns of T-cell and complement-associated genes. Immune cells in TLS expressed essential markers of germinal center formation. Increased activation of tumor-draining lymph nodes in TLS-high patients highlights the relevance of these tumor-related structures to systemic immune response. We identified an overlap of expanded clonotypes in TLS and SLO in B-cell receptor sequencing as an additional correlate of systemic effects of TLS.","dates":{"release":"2025-12-30T00:00:00Z","modification":"2025-12-30T02:02:04.086Z","creation":"2024-09-16T12:04:18.622Z"},"accession":"S-BSST1643","cross_references":{}}