{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["157"],"submitter":["Robert Nshimiyimana"],"species":["Mus musculus (mouse)"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BSST2110"],"repository":["biostudies-other"],"pubmed_authors":["Robert Nshimiyimana","Charles N. Serhan"],"additional_accession":[]},"is_claimable":false,"name":"Traffic-emitted ultrafine particles disrupt macrophage efferocytosis and resolution of allergic lung inflammation","description":"Background: Particulate matter (PM) in air pollution is a major\nhealth concern. PM includes ultrafine particles (UFPs; PM0.1\nand particles of <\n_0.1 \uD835\uDECDm), which can evoke lung inflammation.\nHowever, the impact of UFPs on the resolution of lung\ninflammation, a potentially important link to chronic\ninflammatory diseases, remains to be determined.\nObjective: We sought to investigate the impact of UFPs on the\nresolution of allergic lung inflammation and to identify potential\ntherapeutic interventions to mitigate these effects.\nMethods: UFPs were collected from urban Boston. Using a\nmouse model, transient allergic lung inflammation was induced\nby exposure to house dust mite. Mice were then exposed to\nUFPs, and their inflammatory responses were assessed. The\ntherapeutic potential of a resolution agonist, resolvin D2 (RvD2;\n7S,16R,17S-trihydroxy-4Z,8E,10Z,12E,14E,19Z-\ndocosahexaenoic acid), was also determined.\nResults: UFP exposure impaired lung eosinophil clearance and\nreduced macrophage efferocytosis, key processes in resolving\nlung inflammation. This disruption was mediated by altered\nexpression of ecto-5΄-nucleotidase (Nt5e, gene encoding for\nCD73). Administration of RvD2, a potent proresolving\nmediator, increased macrophage efferocytosis of apoptotic\neosinophils and neutrophils and partially corrected the\nUFP-disrupted resolution mechanisms.\nConclusions: Environmental exposure to traffic-emitted UFPs\ncan fundamentally undermine endogenous resolution processes\n—pathologic mechanisms that can be partially rescued by\nsignaling pathways activated by RvD2. (J Allergy Clin Immunol\n2026;157:238-52.)","dates":{"release":"2025-09-30T00:00:00Z","modification":"2026-05-27T15:30:26.611Z","creation":"2025-06-24T17:55:46.832Z"},"accession":"S-BSST2110","cross_references":{}}