{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Bianca Allen"],"species":["Homo sapiens (human)"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BSST2139"],"repository":["biostudies-other"],"pubmed_authors":["Laneke Luies","Bianca Allen","Robin Wood"],"additional_accession":[]},"is_claimable":false,"name":"Understanding Metabolic Differences in HIV/TB Coinfection: A Sex-Specific Approach ","description":"We conducted a non-targeted, proof-of-concept metabolomics study using two-dimensional gas chromatography time of flight mass spectrometry (GC×GC-TOFMS) to characterise sex-specific metabolite differences in HIV/TB coinfection. Since obtaining large cohorts of untreated HIV/TB coinfected patients is challenging (due to immediate “test-and-treat” policies), we employed an innovative dual-experiment design. Experiment 1 analysed individual urine samples from male and female participants, while Experiment 2 utilised pooled quality control samples for each subgroup to mitigate biological variation and bolster statistical power despite the small sample size. This two-pronged approach was intended to provide exploratory but robust insight into sex-related metabolic disparities in HIV/TB coinfection. Our ultimate goal is to inform future work aimed at tailoring therapeutic interventions and improving diagnostic accuracy and health outcomes for both sexes.\n\nExperiment 1 compared metabolite profiles between females and males within each disease status separately: HCF vs COF (Dataset 1) and HCM vs COM (Dataset 2). \nComparisons were again made between HC and CO within each sex: QHCF vs QCOF (Dataset 3, pooled females) and QHCM vs QCOM (Dataset 4, pooled males). We also performed a four-group comparison (QHCF, QCOF, QHCM, QCOM; Dataset 5) to detect metabolites differing across sex and infection status collectively.","dates":{"release":"2025-08-12T00:00:00Z","modification":"2026-06-16T14:11:20.884Z","creation":"2025-08-12T18:54:23.439Z"},"accession":"S-BSST2139","cross_references":{}}