{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Shakti P Pattanayak"],"species":["Homo sapiens (human)","Mus musculus (mouse)"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BSST2345"],"repository":["biostudies-other"],"additional_accession":["https"],"pubmed_authors":["William C Merrick","Belinda Willard","Timothy A. Chan","Boaz Tirosh","Hong Wang","Zheng-Rong Lu","Shakti P Pattanayak"]},"is_claimable":false,"name":"Inhibition of KDEL receptors remodels the tumor microenvironment for robust T cell independent tumor regression","description":"Tumor immunotherapy is supported by low-grade inflammatory conditions at the microenvironment, triggered by immunogenic cell death (ICD). However, ICD is dampened when tumors acquire resistance, affecting immune recognition. KDEL receptors (KDELRs), through a retrograde Golgi-to-ER transport, prevent spontaneous secretion of KDEL proteins. We report that inhibition of a single KDELR in a minor fraction of tumor cells, primarily KDELR2, provokes robust infiltration of macrophages and neutrophils into the tumor microenvironment, resulting in a complete regression of both immunogenic and non-immunogenic tumors independently of T cells. Importantly, in the course of regression, anti-tumor T cells are primed, conferring protection against a second challenge. Recapitulated by intratumoral delive","dates":{"release":"2025-12-24T00:00:00Z","modification":"2026-05-27T12:34:44.016Z","creation":"2025-12-23T19:37:04.18Z"},"accession":"S-BSST2345","cross_references":{"biostudies":["https"]}}