{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Robert Nshimiyimana"],"species":["Homo sapiens (human)","Mus musculus (mouse)"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BSST2628"],"repository":["biostudies-other"],"pubmed_authors":["Robert Nshimiyimana","Charles N. Serhan","Nan Chiang"],"additional_accession":[]},"is_claimable":false,"name":"Elucidation of a potent pro-resolving mediator of inflammation resolution via human neutrophil–vascular endothelial cell interactions","description":"Significance Statement: Human neutrophil-endothelial interactions biosynthesize a potent pro-resolving molecule from omega-3 DHA via transcellular metabolism, that is also produced by human macrophages solo and mononuclear cells. The proposed bioactive elucidated structure is 4S,13R-dihydroxy-5E,7Z,10Z,14E,16Z,19Z-docosahexaenoic acid, which functions to limit neutrophil infiltration in vivo, reduce neutrophil adherence to endothelial cells, prevent endothelial senescence, as well as counter-regulate proinflammatory cytokines and eicosanoids, and activates human macrophage efferocytosis.","dates":{"release":"2026-03-02T00:00:00Z","modification":"2026-05-31T00:03:33.452Z","creation":"2026-02-11T17:02:44.356Z"},"accession":"S-BSST2628","cross_references":{}}