biostudies-otherUnknownRobert NshimiyimanaHomo sapiens (human)Mus musculus (mouse)https://www.ebi.ac.uk/biostudies/studies/S-BSST2628biostudies-otherRobert NshimiyimanaCharles N. SerhanNan ChiangfalseElucidation of a potent pro-resolving mediator of inflammation resolution via human neutrophil–vascular endothelial cell interactionsSignificance Statement: Human neutrophil-endothelial interactions biosynthesize a potent pro-resolving molecule from omega-3 DHA via transcellular metabolism, that is also produced by human macrophages solo and mononuclear cells. The proposed bioactive elucidated structure is 4S,13R-dihydroxy-5E,7Z,10Z,14E,16Z,19Z-docosahexaenoic acid, which functions to limit neutrophil infiltration in vivo, reduce neutrophil adherence to endothelial cells, prevent endothelial senescence, as well as counter-regulate proinflammatory cytokines and eicosanoids, and activates human macrophage efferocytosis.2026-03-02T00:00:00Z2026-05-31T00:03:33.452Z2026-02-11T17:02:44.356ZS-BSST2628