{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Julia Chen"],"species":["Homo sapiens (human)"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BSST3074"],"repository":["biostudies-other"],"pubmed_authors":["Ewan Millar","Elgene Lim","Julia Chen","Hanyun Zhang","Sunny Z Wu","Lois H Browne","Iveta Slapetova","Alexander Swarbrick","Jodi Lynch","Travis Ruan","Peter H Graham"],"additional_accession":[]},"is_claimable":false,"name":"Stromal cell subsets modulate T-cell infiltration in early breast cancer","description":"Recent studies of the tumour microenvironment have elucidated the heterogeneity of stromal cells, with increasing evidence suggesting that stromal subsets play an important role in regulating anti-tumour immunity in breast cancer. However, the functional diversity of these cells within the tumour immune microenvironment and how they interact with immune cells in a spatial and clinical context remain poorly understood. We performed multiplex immunofluorescence on tumour microarrays from two cohorts consisting of 591 breast cancer patients to assess the abundance and spatial co-localisation of stromal and immune subsets and their correlation with clinicopathological features and patient outcomes. We found that stromal cells were spatially distinct. A perivascular-like subset that was dissemi","dates":{"release":"2026-06-08T00:00:00Z","modification":"2026-09-06T04:20:34.205Z","creation":"2026-06-03T05:21:39.163Z"},"accession":"S-BSST3074","cross_references":{}}