biostudies-otherUnknownJulia ChenHomo sapiens (human)https://www.ebi.ac.uk/biostudies/studies/S-BSST3074biostudies-otherEwan MillarElgene LimJulia ChenHanyun ZhangSunny Z WuLois H BrowneIveta SlapetovaAlexander SwarbrickJodi LynchTravis RuanPeter H GrahamfalseStromal cell subsets modulate T-cell infiltration in early breast cancerRecent studies of the tumour microenvironment have elucidated the heterogeneity of stromal cells, with increasing evidence suggesting that stromal subsets play an important role in regulating anti-tumour immunity in breast cancer. However, the functional diversity of these cells within the tumour immune microenvironment and how they interact with immune cells in a spatial and clinical context remain poorly understood. We performed multiplex immunofluorescence on tumour microarrays from two cohorts consisting of 591 breast cancer patients to assess the abundance and spatial co-localisation of stromal and immune subsets and their correlation with clinicopathological features and patient outcomes. We found that stromal cells were spatially distinct. A perivascular-like subset that was dissemi2026-06-08T00:00:00Z2026-09-06T04:20:34.205Z2026-06-03T05:21:39.163ZS-BSST3074