{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Matthew Wiest"],"species":["Mus musculus (mouse)"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-BSST3402"],"repository":["biostudies-other"],"pubmed_authors":["Vivian Yan","Seok-Chan Park","Chun Chen","Pamela T Wong","Moataz Noureddine","Adolfo Garcia-Sastre","James R Baker Jr","Michael Schotsaert","Katarzyna W Janczak","Jessica J O’Konek","Dilara Karadag","Matthew Wiest","Julianne d’Acunzo","Mohammad Farazuddin","Chinghan Chung","Gabriel Laghlali"],"additional_accession":[]},"is_claimable":false,"name":"Spatiotemporal heterologous vaccination relies on type I interferons at priming to enhance mucosal immunity","description":"Parenteral vaccines against respiratory viruses poorly block infection and transmission due to suboptimal induction of mucosal immunity. In contrast, hybrid immunity and heterologous-route immunization regimens generate protective mucosal and systemic immunity. Herein, we examine how chronological order in heterologous prime/boost immunization regimens impacts immune responses using combinations of intramuscular mRNA and intranasal adjuvanted subunit vaccines against SARS-CoV-2. Enhanced long-lived mucosal and systemic immunity depended strongly on vaccine delivery sequence, with heterologous regimens administered in alternate order of routes yielding markedly distinct immune profiles with different Th-biases and divergent localizations. Immunity imparted through heterologous immunization ","dates":{"release":"2026-09-23T00:00:00Z","modification":"2026-09-23T16:20:06.398Z","creation":"2026-09-21T18:05:26.641Z"},"accession":"S-BSST3402","cross_references":{}}