biostudies-otherUnknownhttps://www.ebi.ac.uk/biostudies/studies/S-DIXA-D-1094Cardio disease collectionbiostudies-otherfalseGene Expression Analysis of Blood Reveals S100A11 and AQP9 as Potential Biomarkers of Infective EndocarditisBackground—Diagnosis and pronostic assessment are challenging in infective endocarditis (IE). To investigate the host response during IE and identify potential biomarkers, we determined the circulating gene expression profile through a whole genome microarray analysis. Methods and Results—A transcriptomic case-control study was performed on blood samples from patients with native valve IE (n=39), excluded IE after an initial suspicion (n=10) at patient’s admission, and age-matched healthy controls (n=10). The whole genome microarray analysis showed that patients with IE exhibited a specific transcriptional program with a predominance of gene categories associated with cell activation, innate immune and inflammatory responses. These categories were organized in a dense network from which ar2016-05-11T14:27:26Z2016-05-11T14:27:26Z2016-05-11T09:53:34ZS-DIXA-D-1094GSE29161E-GEOD-29161