{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"submitter":["Chang YC"],"pagination":["5054-5063"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-10856"],"project":["EurocanPlatform"],"abstract":["\"Decoy receptor 3 (DcR3) is a member of the TNF receptor superfamily and is up-regulated in tumors that originate from a diversity of lineages. DcR3 is capable of promoting angiogenesis, inducing dendritic cell apoptosis, and modulating macrophage differentiation. Since tumor-associated macrophages (TAMs) are the major infiltrating leukocytes in most malignant tumors, we used microarray technology to investigate whether DcR3 contributes to the development of TAMs. Among the DcR3-modulated genes expressed by TAMs, those that encode proteins involved in MHC class II (MHC-II)-dependent antigen presentation were down-regulated substantially, together with the master regulator of MHC-II expression (the class II transactivator, CIITA). The ERK- and JNK-induced deacetylation of histones associate"],"repository":["biostudies-other"],"experiment_type":["transcription profiling by array"],"data_source":["EurocanPlatform"],"omics_type":["Unknown"],"volume":["111"],"journal":["Blood"],"species":["Homo sapiens"],"pubmed_authors":["Hsieh SL","Lee CT","Chen TC","Yang CY","Wang CC","Wang HW","Chang YC"],"additional_accession":[]},"is_claimable":false,"name":"Transcription profiling by array of human monocytes were cultured with DcR3 in the presence of M-CSF","description":"\"Decoy receptor 3 (DcR3) is a member of the TNF receptor superfamily and is up-regulated in tumors that originate from a diversity of lineages. DcR3 is capable of promoting angiogenesis, inducing dendritic cell apoptosis, and modulating macrophage differentiation. Since tumor-associated macrophages (TAMs) are the major infiltrating leukocytes in most malignant tumors, we used microarray technology to investigate whether DcR3 contributes to the development of TAMs. Among the DcR3-modulated genes expressed by TAMs, those that encode proteins involved in MHC class II (MHC-II)-dependent antigen presentation were down-regulated substantially, together with the master regulator of MHC-II expression (the class II transactivator, CIITA). The ERK- and JNK-induced deacetylation of histones associate","dates":{"release":"2016-04-14T13:27:21Z","publication":"2008 May","modification":"2016-04-14T13:27:21Z","creation":"2016-04-14T13:27:21Z"},"accession":"S-ECPF-GEOD-10856","cross_references":{"GEO":["GSE10856"],"ArrayExpress":["E-GEOD-10856"],"EFO":["EFO_0000322","EFO_0000311"],"ArrayExpress files":["E-GEOD-10856"]}}