biostudies-otherChang YC5054-5063https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-10856EurocanPlatform"Decoy receptor 3 (DcR3) is a member of the TNF receptor superfamily and is up-regulated in tumors that originate from a diversity of lineages. DcR3 is capable of promoting angiogenesis, inducing dendritic cell apoptosis, and modulating macrophage differentiation. Since tumor-associated macrophages (TAMs) are the major infiltrating leukocytes in most malignant tumors, we used microarray technology to investigate whether DcR3 contributes to the development of TAMs. Among the DcR3-modulated genes expressed by TAMs, those that encode proteins involved in MHC class II (MHC-II)-dependent antigen presentation were down-regulated substantially, together with the master regulator of MHC-II expression (the class II transactivator, CIITA). The ERK- and JNK-induced deacetylation of histones associatebiostudies-othertranscription profiling by arrayEurocanPlatformUnknown111BloodHomo sapiensHsieh SLLee CTChen TCYang CYWang CCWang HWChang YCfalseTranscription profiling by array of human monocytes were cultured with DcR3 in the presence of M-CSF"Decoy receptor 3 (DcR3) is a member of the TNF receptor superfamily and is up-regulated in tumors that originate from a diversity of lineages. DcR3 is capable of promoting angiogenesis, inducing dendritic cell apoptosis, and modulating macrophage differentiation. Since tumor-associated macrophages (TAMs) are the major infiltrating leukocytes in most malignant tumors, we used microarray technology to investigate whether DcR3 contributes to the development of TAMs. Among the DcR3-modulated genes expressed by TAMs, those that encode proteins involved in MHC class II (MHC-II)-dependent antigen presentation were down-regulated substantially, together with the master regulator of MHC-II expression (the class II transactivator, CIITA). The ERK- and JNK-induced deacetylation of histones associate2016-04-14T13:27:21Z2008 May2016-04-14T13:27:21Z2016-04-14T13:27:21ZS-ECPF-GEOD-10856GSE10856E-GEOD-10856EFO_0000322EFO_0000311E-GEOD-10856