{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"submitter":["Thorner AR"],"pagination":["742-751"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-11429"],"project":["EurocanPlatform"],"abstract":["The basal-like breast cancer subtype portends a poor clinical prognosis, and a defining feature of this subtype is the high expression of genes in the “proliferation signature”.  B-Myb, a member of the MYB protein family of transcription factors, is highly expressed in the proliferation signature and is amplified and overexpressed in a variety of tumor types, including breast.  In this report we demonstrated that B-Myb is highly expressed in basal-like breast cancer relative to the other subtypes, and B-Myb expression alone is prognostic. We also identified an association between a nonsynonymous B-Myb germline variant (S427G, rs2070235) and an increased risk of having a basal-like breast cancer among patients with breast cancer.  The expression of B-Myb, or the S427G variant, was manipulat"],"repository":["biostudies-other"],"experiment_type":["transcription profiling by array"],"data_source":["EurocanPlatform"],"omics_type":["Unknown"],"volume":["28"],"journal":["Oncogene"],"species":["Homo sapiens"],"pubmed_authors":["Millikan RC","Winkel S","Hoadley KA","Parker JS","Thorner AR","Perou CM"],"additional_accession":[]},"is_claimable":false,"name":"Transcription profiling of human basal-like breast cancer - in vitro and in vivo Analysis of B-Myb","description":"The basal-like breast cancer subtype portends a poor clinical prognosis, and a defining feature of this subtype is the high expression of genes in the “proliferation signature”.  B-Myb, a member of the MYB protein family of transcription factors, is highly expressed in the proliferation signature and is amplified and overexpressed in a variety of tumor types, including breast.  In this report we demonstrated that B-Myb is highly expressed in basal-like breast cancer relative to the other subtypes, and B-Myb expression alone is prognostic. We also identified an association between a nonsynonymous B-Myb germline variant (S427G, rs2070235) and an increased risk of having a basal-like breast cancer among patients with breast cancer.  The expression of B-Myb, or the S427G variant, was manipulat","dates":{"release":"2016-04-14T13:28:26Z","publication":"2009 Feb","modification":"2016-04-14T13:28:26Z","creation":"2016-04-14T13:28:26Z"},"accession":"S-ECPF-GEOD-11429","cross_references":{"GEO":["GSE11429"],"ArrayExpress":["E-GEOD-11429"],"EFO":["EFO_0000305","EFO_0000322"],"ArrayExpress files":["E-GEOD-11429"]}}