{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Moreno-Bueno Gema"],"species":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-13362"],"project":["EurocanPlatform"],"abstract":["Alterations in the cadherin-catenin adhesion complexes are involved in tumor initiation, progression and metastasis. However, the functional implication of distinct cadherin types in breast cancer biology is still poorly understood. Methods: To compare the functional role of E-cadherin and P-cadherin in invasive breast cancer, we stably transfected these molecules into the MDA-MB-231 cell line, and investigated their effects on motility, invasion and gene expression regulation. Expression of either E- and P-cadherin significantly increased cell aggregation and induced a switch from fibroblastic to epithelial morphology. Although expression of these cadherins did not completely reverse the mesenchymal phenotype of MDA-MB-231 cells, both E- and P-cadherin decreased fibroblast-like migration "],"repository":["biostudies-other"],"experiment_type":["transcription profiling by array"],"data_source":["EurocanPlatform"],"pubmed_authors":["Cano Amaparo","Hergueta-Redondo Marta","Moreno-Bueno Gema","Sarrio David","Palacios Jose"],"additional_accession":[]},"is_claimable":false,"name":"Functional characterization of E- and P-cadherin in invasive breast cancer cells","description":"Alterations in the cadherin-catenin adhesion complexes are involved in tumor initiation, progression and metastasis. However, the functional implication of distinct cadherin types in breast cancer biology is still poorly understood. Methods: To compare the functional role of E-cadherin and P-cadherin in invasive breast cancer, we stably transfected these molecules into the MDA-MB-231 cell line, and investigated their effects on motility, invasion and gene expression regulation. Expression of either E- and P-cadherin significantly increased cell aggregation and induced a switch from fibroblastic to epithelial morphology. Although expression of these cadherins did not completely reverse the mesenchymal phenotype of MDA-MB-231 cells, both E- and P-cadherin decreased fibroblast-like migration ","dates":{"release":"2016-04-14T13:31:02Z","modification":"2016-04-14T13:31:02Z","creation":"2016-04-14T13:31:02Z"},"accession":"S-ECPF-GEOD-13362","cross_references":{"GEO":["GSE13362"],"ArrayExpress":["E-GEOD-13362"],"EFO":["EFO_0000305","EFO_0000322"],"ArrayExpress files":["E-GEOD-13362"]}}