biostudies-otherUnknownMoreno-Bueno GemaHomo sapienshttps://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-13362EurocanPlatformAlterations in the cadherin-catenin adhesion complexes are involved in tumor initiation, progression and metastasis. However, the functional implication of distinct cadherin types in breast cancer biology is still poorly understood. Methods: To compare the functional role of E-cadherin and P-cadherin in invasive breast cancer, we stably transfected these molecules into the MDA-MB-231 cell line, and investigated their effects on motility, invasion and gene expression regulation. Expression of either E- and P-cadherin significantly increased cell aggregation and induced a switch from fibroblastic to epithelial morphology. Although expression of these cadherins did not completely reverse the mesenchymal phenotype of MDA-MB-231 cells, both E- and P-cadherin decreased fibroblast-like migration biostudies-othertranscription profiling by arrayEurocanPlatformCano AmaparoHergueta-Redondo MartaMoreno-Bueno GemaSarrio DavidPalacios JosefalseFunctional characterization of E- and P-cadherin in invasive breast cancer cellsAlterations in the cadherin-catenin adhesion complexes are involved in tumor initiation, progression and metastasis. However, the functional implication of distinct cadherin types in breast cancer biology is still poorly understood. Methods: To compare the functional role of E-cadherin and P-cadherin in invasive breast cancer, we stably transfected these molecules into the MDA-MB-231 cell line, and investigated their effects on motility, invasion and gene expression regulation. Expression of either E- and P-cadherin significantly increased cell aggregation and induced a switch from fibroblastic to epithelial morphology. Although expression of these cadherins did not completely reverse the mesenchymal phenotype of MDA-MB-231 cells, both E- and P-cadherin decreased fibroblast-like migration 2016-04-14T13:31:02Z2016-04-14T13:31:02Z2016-04-14T13:31:02ZS-ECPF-GEOD-13362GSE13362E-GEOD-13362EFO_0000305EFO_0000322E-GEOD-13362