{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"submitter":["Marotta LL"],"pagination":["2723-2735"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-22917"],"project":["EurocanPlatform"],"abstract":["To investigate potential links between Stat3 transcriptional activity and other signaling pathways in breast cancer, we determined the gene expression profiles of three breast cancer cell lines treated with JAK, PTGIS, PFKFB3, CXCR2, HAS1, or NQO1 inhibitor (all of which decreased Stat3 transcriptional activity in Hs 578T cells except for the NQO1 inhibitor), inhibitor treatment vehicle alone (DMSO), STAT3 siRNAs, or non-targeting siRNAs. Using the resulting data, we identified a gene signature that was significantly regulated by STAT3 siRNAs and similarly affected by the JAK and at least 3 other inhibitors (or by 4 other inhibitors) but not by the NQO1 inhibitor in Hs 578T cells that was enriched in genes involved in development and correlated with shorter distant metastasis-free survival"],"repository":["biostudies-other"],"experiment_type":["RNA-seq of coding RNA"],"data_source":["EurocanPlatform"],"omics_type":["Unknown"],"volume":["121"],"journal":["The Journal of clinical investigation"],"species":["Homo sapiens"],"pubmed_authors":["Huh SJ","Kim SY","Nikolskaya T","Choudhury SA","Park SY","Maruyama R","Mulvey LA","Liu XS","Wu Z","Polyak K","Nikolsky Y","Richardson AL","Lee HE","Anderson KS","Hahn WC","Silver SJ","Kim JJ","Root DE","Walker SR","Almendro V","Shipitsin M","Marusyk A","Bloushtain-Qimron N","Marotta LL","Gönen M","Frank DA","Schemme J","Bessarabova MO"],"additional_accession":[]},"is_claimable":false,"name":"SAGE-Seq gene expression profiles of Hs578T, MCF7, and SUM159PT cells treated with STAT3 or non-targeting siRNAs, DMSO, or CXCR2, PTGIS, HAS1, PFKFB3, JAK, or NQO1 inhibitor","description":"To investigate potential links between Stat3 transcriptional activity and other signaling pathways in breast cancer, we determined the gene expression profiles of three breast cancer cell lines treated with JAK, PTGIS, PFKFB3, CXCR2, HAS1, or NQO1 inhibitor (all of which decreased Stat3 transcriptional activity in Hs 578T cells except for the NQO1 inhibitor), inhibitor treatment vehicle alone (DMSO), STAT3 siRNAs, or non-targeting siRNAs. Using the resulting data, we identified a gene signature that was significantly regulated by STAT3 siRNAs and similarly affected by the JAK and at least 3 other inhibitors (or by 4 other inhibitors) but not by the NQO1 inhibitor in Hs 578T cells that was enriched in genes involved in development and correlated with shorter distant metastasis-free survival","dates":{"release":"2016-04-14T13:45:15Z","publication":"2011 Jul","modification":"2016-04-14T13:45:15Z","creation":"2016-04-14T13:45:15Z"},"accession":"S-ECPF-GEOD-22917","cross_references":{"GEO":["GSE22917"],"ArrayExpress":["E-GEOD-22917"],"EFO":["EFO_0000305","EFO_0000322"],"ArrayExpress files":["E-GEOD-22917"]}}