biostudies-otherBekhouche Ie16950https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-23720EurocanPlatformInflammatory breast cancer (IBC) is an aggressive form of BC poorly defined at the molecular level. We compared the molecular portraits of 63 IBC and 134 non-IBC (nIBC) clinical samples. Genomic imbalances of 49 IBCs and 124 nIBCs were determined using high-resolution array-comparative genomic hybridization, and mRNA expression profiles of 197 samples using whole-genome microarrays. Genomic profiles of IBCs were as heterogeneous as those of nIBCs, and globally relatively close. However, IBCs showed more frequent “complex” patterns and a higher percentage of genes with CNAs per sample. The number of altered regions was similar in both types, although some regions were altered more frequently and/or with higher amplitude in IBCs. Many genes were similarly altered in both types; however, morebiostudies-othertranscription profiling by array, comparative genomic hybridization by arrayEurocanPlatformUnknown6PloS oneHomo sapiensViens PBekhouche ICharpin CBirnbaum DHouvenaeghel GBidaut GFinetti PCharafe-Jauffret EBertucci FTarpin CFerrari AChaffanet MAdelaïde JJacquemier JfalseHigh-resolution comparative genomic hybridization of inflammatory breast cancer and identification of candidate genesInflammatory breast cancer (IBC) is an aggressive form of BC poorly defined at the molecular level. We compared the molecular portraits of 63 IBC and 134 non-IBC (nIBC) clinical samples. Genomic imbalances of 49 IBCs and 124 nIBCs were determined using high-resolution array-comparative genomic hybridization, and mRNA expression profiles of 197 samples using whole-genome microarrays. Genomic profiles of IBCs were as heterogeneous as those of nIBCs, and globally relatively close. However, IBCs showed more frequent “complex” patterns and a higher percentage of genes with CNAs per sample. The number of altered regions was similar in both types, although some regions were altered more frequently and/or with higher amplitude in IBCs. Many genes were similarly altered in both types; however, more2016-04-14T13:46:46Z20112016-04-14T13:46:46Z2016-04-14T13:46:46ZS-ECPF-GEOD-23720GSE23720E-GEOD-23720EFO_0000635EFO_0000305E-GEOD-23720