{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Saintigny Pierre"],"species":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-31852"],"project":["EurocanPlatform"],"abstract":["EGFR-mutated non-small cell lung cancers bear hallmarks including sensitivity to EGFR inhibitors,  and low proliferation, and increased MET.  However, the biology of EGFR dependence is still poorly understood. Using a training cohort of chemo-naive lung adenocarcinomas, we have developed a 72-gene signature that predicts (i) EGFR mutation status in four independent datasets; (ii) sensitivity to erlotinib in vitro; and (iii) improved survival, even in the wild-type EGFR subgroup. The signature includes differences associated with enhanced receptor tyrosine kinase (RTK) signaling, such as increased expression of endocytosis-related genes, decreased phosphatase levels, decreased expression of proliferation-related genes, increased folate receptor-1 (FOLR1) (a determinant of pemetrexed respons"],"repository":["biostudies-other"],"experiment_type":["transcription profiling by array"],"data_source":["EurocanPlatform"],"pubmed_authors":["Heymach John","Coombes Kevin","Kim Edward","Lee J","Wistuba Ignacio","Herbst Roy","Saintigny Pierre","Lippman Scott","Hong Waun","Mao Li"],"additional_accession":[]},"is_claimable":false,"name":"An EGFR-mutation signature reveals features of the EGFR-dependent phenotype and identifies MACC1 as an EGFR-associated regulator of MET","description":"EGFR-mutated non-small cell lung cancers bear hallmarks including sensitivity to EGFR inhibitors,  and low proliferation, and increased MET.  However, the biology of EGFR dependence is still poorly understood. Using a training cohort of chemo-naive lung adenocarcinomas, we have developed a 72-gene signature that predicts (i) EGFR mutation status in four independent datasets; (ii) sensitivity to erlotinib in vitro; and (iii) improved survival, even in the wild-type EGFR subgroup. The signature includes differences associated with enhanced receptor tyrosine kinase (RTK) signaling, such as increased expression of endocytosis-related genes, decreased phosphatase levels, decreased expression of proliferation-related genes, increased folate receptor-1 (FOLR1) (a determinant of pemetrexed respons","dates":{"release":"2016-04-14T14:01:52Z","modification":"2016-04-14T14:01:52Z","creation":"2016-04-14T14:01:52Z"},"accession":"S-ECPF-GEOD-31852","cross_references":{"GEO":["GSE31852"],"ArrayExpress":["E-GEOD-31852"],"EFO":["EFO_0000635","EFO_0005288"],"ArrayExpress files":["E-GEOD-31852"]}}