{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"submitter":["Wardell SE"],"pagination":["1235-1248"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-35428"],"project":["EurocanPlatform"],"abstract":["In this study, we have utilized microarray analysis to directly compare a subset of structurally distinct, clinically relevant SERMs in the presence and absence of estradiol, using a high replicate number (10) to ensure detection of modestly regulated genes. Tested compounds included 4-hydroxytamoxifen, ICI-182,780, Raloxifene, Bazedoxifene and Lasofoxifene. MCF-7 cells were treates with indicated SERMs in the presence of E2 or vehicle; RNA was isolated and used for preparation of label for 3' expression analysis."],"repository":["biostudies-other"],"experiment_type":["transcription profiling by array"],"data_source":["EurocanPlatform"],"omics_type":["Unknown"],"volume":["26"],"journal":["Molecular endocrinology (Baltimore, Md.)"],"species":["Homo sapiens"],"pubmed_authors":["McDonnell DP","Kazmin D","Wardell SE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional profiling of clinically relevant SERMs and SERM/estradiol complexes in a cellular model of breast cancer","description":"In this study, we have utilized microarray analysis to directly compare a subset of structurally distinct, clinically relevant SERMs in the presence and absence of estradiol, using a high replicate number (10) to ensure detection of modestly regulated genes. Tested compounds included 4-hydroxytamoxifen, ICI-182,780, Raloxifene, Bazedoxifene and Lasofoxifene. MCF-7 cells were treates with indicated SERMs in the presence of E2 or vehicle; RNA was isolated and used for preparation of label for 3' expression analysis.","dates":{"release":"2016-04-14T14:07:16Z","publication":"2012 Jul","modification":"2016-04-14T14:07:16Z","creation":"2016-04-14T14:07:16Z"},"accession":"S-ECPF-GEOD-35428","cross_references":{"GEO":["GSE35428"],"ArrayExpress":["E-GEOD-35428"],"EFO":["EFO_0000305","EFO_0000322"],"ArrayExpress files":["E-GEOD-35428"]}}