biostudies-otherWardell SE1235-1248https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-35428EurocanPlatformIn this study, we have utilized microarray analysis to directly compare a subset of structurally distinct, clinically relevant SERMs in the presence and absence of estradiol, using a high replicate number (10) to ensure detection of modestly regulated genes. Tested compounds included 4-hydroxytamoxifen, ICI-182,780, Raloxifene, Bazedoxifene and Lasofoxifene. MCF-7 cells were treates with indicated SERMs in the presence of E2 or vehicle; RNA was isolated and used for preparation of label for 3' expression analysis.biostudies-othertranscription profiling by arrayEurocanPlatformUnknown26Molecular endocrinology (Baltimore, Md.)Homo sapiensMcDonnell DPKazmin DWardell SEfalseTranscriptional profiling of clinically relevant SERMs and SERM/estradiol complexes in a cellular model of breast cancerIn this study, we have utilized microarray analysis to directly compare a subset of structurally distinct, clinically relevant SERMs in the presence and absence of estradiol, using a high replicate number (10) to ensure detection of modestly regulated genes. Tested compounds included 4-hydroxytamoxifen, ICI-182,780, Raloxifene, Bazedoxifene and Lasofoxifene. MCF-7 cells were treates with indicated SERMs in the presence of E2 or vehicle; RNA was isolated and used for preparation of label for 3' expression analysis.2016-04-14T14:07:16Z2012 Jul2016-04-14T14:07:16Z2016-04-14T14:07:16ZS-ECPF-GEOD-35428GSE35428E-GEOD-35428EFO_0000305EFO_0000322E-GEOD-35428