{"database":"biostudies-other","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Denvir James"],"species":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-ECPF-GEOD-36081"],"project":["EurocanPlatform"],"abstract":["Grainyhead genes are involved in wound healing and developmental neural tube closure. In light of the high degree of similarity between the epithelial-mesenchymal transitions (EMTs) occurring in wound healing processes and the cancer stem cell-like compartment of tumors, including TGF-β-dependence, we investigated the role of a Grainyhead gene (GRHL2) in oncogenic EMT.  Grainyhead was specifically down-regulated in the claudin-low subclass of mammary tumors and in the basal-B subclass of breast cancer cell lines.  Functionally, GRHL2 suppressed TGF-β-induced, Twist-induced or spontaneous EMT, enhanced anoikis-sensitivity, and suppressed mammosphere generation in mammary epithelial cells.   These effects were mediated, in part, by its suppression of ZEB1 expression, through direct repressio"],"repository":["biostudies-other"],"experiment_type":["transcription profiling by array"],"data_source":["EurocanPlatform"],"pubmed_authors":["Ivanov Alexey","Widmeyer Joseph","Denvir James","Frisch Steven","Pifer Phillip","Cieply Benjamin","Riley Philip","Addison Joseph"],"additional_accession":[]},"is_claimable":false,"name":"Effect of GRHL2 in HMLE+Twist-ER+4-OHT cells","description":"Grainyhead genes are involved in wound healing and developmental neural tube closure. In light of the high degree of similarity between the epithelial-mesenchymal transitions (EMTs) occurring in wound healing processes and the cancer stem cell-like compartment of tumors, including TGF-β-dependence, we investigated the role of a Grainyhead gene (GRHL2) in oncogenic EMT.  Grainyhead was specifically down-regulated in the claudin-low subclass of mammary tumors and in the basal-B subclass of breast cancer cell lines.  Functionally, GRHL2 suppressed TGF-β-induced, Twist-induced or spontaneous EMT, enhanced anoikis-sensitivity, and suppressed mammosphere generation in mammary epithelial cells.   These effects were mediated, in part, by its suppression of ZEB1 expression, through direct repressio","dates":{"release":"2016-04-14T14:08:00Z","modification":"2016-04-14T14:08:00Z","creation":"2016-04-14T14:08:00Z"},"accession":"S-ECPF-GEOD-36081","cross_references":{"GEO":["GSE36081"],"ArrayExpress":["E-GEOD-36081"],"EFO":["EFO_0000305","EFO_0000322"],"ArrayExpress files":["E-GEOD-36081"]}}